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For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome. nature.com/articles/s4158…

Gut microbiota could be crucial to the success or failure of immunotherapy nature.com/articles/d4158…

Excited to share our new story freshly out in Nature Immunology, answering the key question, how do memory B cells (MBC), upon antigen recall, decide to participate in secondary germinal centers (GC) or become plasma cells (PC)? Quite relevant to HIV bnAb vac nature.com/articles/s4159…

ISHAS is announcing a call for ISHAS Research Grants, ISHAS Research Travel Grants, and ISHAS Personal Scholarships. For more information visit ishas.org/affiliates/res… These grants and scholarships are supported by the ISHAS Corporate Affiliates Program.

Finished my first week as a new PI! I still can’t quite believe it, but am so excited for what is to come! I feel so lucky that I get to spend my life asking interesting questions (and hopefully helping to answer some) about how the immune system and bladder cancer interact!

A must-read for anyone in the nanomedicine field, straight from the greats Pieter Cullis and Phil Felgner themselves! nature.com/articles/s4157…

Published today! We found that cancer cells adapting to drug treatments don't simply switch from a sensitive to resistant state; instead there's a ‘resistance continuum’ of resistant phenotypes with epigenetically reprogrammed states. 🧵⬇️ nature.com/articles/s4158… Gustavo França

Fibroblasts are everywhere in our tissue as structural cells, yet we are only beginning to understand them. Today in nature, we report that lung-specialized alveolar fibroblasts orchestrate lung homeostasis, inflammation, and fibrosis. 🧵👇(1/n) nature.com/articles/s4158…

Excited to be on this panel as part of a fun night of science and comedy! Come and join the event to support a good cause! eventbrite.ca/e/science-stan…

Neuro-immune crosstalk in hematopoiesis, inflammation, and repair dlvr.it/T9n46r #immunology

Amen! Anyone else drowning in 300 emails/day & meetings and fighting to get that critical thinking & reading time? Perhaps contracts need to include protected hrs/week? Science must protect thinking time in a world of instant communication nature.com/articles/d4158…

Mice live longer and healthier lives when a cytokine protein called IL-11 is inhibited go.nature.com/3Yk3ylz

Much of dementia—perhaps half—could be prevented or substantially delayed with attention to 14 modifiable risk factors The Lancet Commission 2024 report thelancet.com/journals/lance… New inclusion of cholesterol and vision loss as risk factors

Ok, this is amazing: 1/ Canadian and Brazilian players are having a heated chat at the net during the women’s beach volleyball gold medal match 2/ DJ plays John Lennon’s ‘Imagine’ 3/ Players look at one another and smile 4/ Crowd starts singing along

🧵(1/) I am SO proud of our work finally showing how microbiome and antibiotics sculpt the newborn immune response to be pro-allergic: Microbial intestinal dysbiosis drives long-term allergic susceptibilit... sciencedirect.com/science/articl… CIHR University of British Columbia AllerGen Network Stem Cell Network

Astonishing breakthrough in #organoid engineering, as reported in nature by T Recaldin,M Harter,L Steinacher,B Gjeta, and colleagues: intestinal epithelial organoids incorporating tissue-resident immune cells. Institute of Human Biology Roche go.roche.com/4a5t1

SBME and Djavad Mowafaghian Centre for Brain Health are hiring an Assistant Professor (Tenure Track) in Neuro Bioengineering to lead a collaborative and convergent research program at the interface of engineering and molecular/cellular neuroscience. Learn more: bit.ly/3AJTbxB

Welcome to being a PI

An absolutely remarkable #Covid paper from UCSF. What did they find? 1. Fibrin binds spike protein 2. Forms proinflammatory blood clots 3. Clots drive systemic thromboinflammation & brain pathology, including #LongCovid 4. NK cell loss is seen & explains increase in #cancer

New report of a nasal vaccine booster provides strong, durable #SARSCoV2 cross-variant protection—preventing infection— compared with shots in non-human primates nature.com/articles/s4159… Nature Immunology