Twitter Beğeni Hilesi

When I started my work on that project, it was just a #protein to solve the structure of. Hundreds of hours, optimizations, attempts - and of course also failures - later, we put together an awesome story. (1/3)

Today we report on a programmable technology for large-scale gene integration into the genome in Nature Biotechnology which tries to solve a long-standing challenge in the gene editing field nature.com/articles/s4158… w Jonathan Gootenberg Massachusetts Institute of Technology (MIT) 1/x

UPDATE: accelerated preview published (with minor revisions) at nature: rdcu.be/c0zBn. Special thanks to all 3 reviewers for their kind words, thoughtful questions and insightful critiques! It was the kind of review process every scientist dreams about!

Check out this animation of the CyanoClock that Carrie Partch and I worked on with Janet Iwasa and her postdoc Franchescka Lopez Rivera. We did our best to represent the past 25ish years of research on this amazing system!

Our small discovery just got published 😇. Relatively few cyanobacterial genomes are home to most known families of CRISPR-Cas transposons (CAST). After a careful search, we found a new capture: type I-D CAST~ academic.oup.com/nar/advance-ar… Joseph E. Peters

Thrilled to release our manuscript on biorxiv! Sanne Klompe and I investigated a CRISPR-associated transposon (CAST), uncovering a novel cellular factor and molecular requirements that will be critical for genome engineering. (1/7) biorxiv.org/content/10.110…

1/n After an arduous but constructive peer review process, we’re excited to share the published version of this work. Lots of added goodies: science.org/doi/10.1126/sc…

Hot off the press (and after lengthy review) from the Joseph E. Peters, @Kellogg_liz, and Ailong Ke lab published today in Molecular Cell : tinyurl.com/2zs4vmuw This work was led by the amazing Jung-Un Park Mike Petassi popo and Eshan Mehrotra (an undergrad at the time!)

In an exceedingly rare occurrence I'm using social media for shameless self-promotion--in this case the bulk of my PhD work finally being published almost 7 years after I started it. pnas.org/doi/full/10.10…

Our rubisco review is finally out-out, now with page numbers and some supplementary files that we hope will be useful. File S1: A list of all of the known types of rubisco annualreviews.org/doi/full/10.11…

In the first preprint of the weekend, Luke Oltrogge et al. find that the size of α-carboxysomes is strongly specified by CsoS2 and, in particular, the relative abundance of M- and C-type peptide repeats. ⬇️biorxiv.org/content/10.110…

We are super excited to share our work unraveling the mechanistic intricacies of target site selection by type V-K CRISPR-associated transposases now available as a preprint on bioRxiv!🧬 biorxiv.org/content/10.110… 1/16

📢 We are hiring! PhD and Postdoc positions available in my new lab at the Max Perutz Labs Vienna on the Vienna BioCenter campus. If you are interested in the mechanisms, functions and applications of transposons, just write me at [email protected]. Please, RT!

🚨Thrilled to unveil Cress Lab's 1st pre-print! In work co-led with my former Doudna Lab-mates Ben Adler & Muntathar Al-Shimary, we establish a phage functional genomics platform to characterize the genomes of diverse lytic phages. 🧬biorxiv.org/content/10.110… 1/

Very excited to share our preprint "Computational design of sequence-specific DNA-binding proteins"! biorxiv.org/content/10.110…

New pre-print from the Sternberg Lab! Transposon-encoded nucleases (TnpB/IscB) gave rise to the CRISPR-associated proteins (Cas9 and Cas12), but were TnpB-like proteins domesticated for other functions? 𝙔𝙀𝙎!! doi.org/10.1101/2023.1…

What limits rubisco function? Is it the chemical mechanism? Evolution? In an updated pre-print Michael Prywes et. al explore this question by assaying >99% of single amino acid mutants in Form II rubisco (1/7)

I am delighted to share the newest work from the Sternberg Lab, in which we discover RNA-templated gene creation as a mechanism of antiviral immunity. This is a story for anyone who loves molecular biology, and one that repeatedly left us in disbelief. doi.org/10.1101/2024.0…

Honored and excited to be part of this year's Jane Coffin Childs Memorial Fund cohorts! Deeply grateful to Liz Kellogg ❄️🔬 for the incredible mentorship during my PhD journey. Looking forward to collaborating with the amazing teams at Savage Lab and Dave Savage!

Excited about phage functional genomics, phage engineering, & microbiome editing? The Cress Lab UC Berkeley Innovative Genomics Institute is hiring postdocs in these areas! Come chat w/ me Viruses of Microbes 2024 & don't miss my presentation w/ Ben Adler in the SynBio session Fri @ 11:20am. Retweets appreciated!