Twitter Beğeni Hilesi

#Centriole docking initiated at different stages in #cilia deconstruction could account for the variety of intermediates observed. From study by Ott and Constable et al. Lippincott-Schwartz Lab Saikat Mukhopadhyay: hubs.la/Q02L7cxN0 #Development #Neuroscience

.Rodal Lab (hubs.la/Q02LVJkn0) show that for 2 different signaling molecules at the #Drosophila neuromuscular junction, #neurons release EVs most likely as a disposal mechanism—not to signal across the #synapse. Spotlight by Bostelman & Broihier: hubs.la/Q02LVGsD0

The mitochondrial fission and fusion machinery perform competing roles in mitochondrial-derived compartments (MDC) formation. From Wilson Adam Hughes et al showing that MDCs are multilamellar domains that encase membrane cargo and cytosol: hubs.la/Q02L7nV80 #mitochondria

Overloading the outer mitochondrial membrane (OMM) with membrane proteins induces mitochondrial-derived compartment formation (MDC). From Wilson, Adam Hughes and colleagues showing that MDCs remove surplus proteins from the OMM: hubs.la/Q02L7nd_0 #mitochondria

Ballmer, @bungoakiyoshi.bsky.social Department of Biochemistry at Oxford University WTCCB Cell Biology and colleagues investigate the role of Aurora B in regulating chromosome segregation in Trypanosoma brucei, whose #kinetochores consist of unique proteins. hubs.la/Q02MVpvb0

Huang, Luo, Peng et al. Zhejiang University find that increases in intracellular lactate induce TFEB lactylation. Lactylation at K91 protects TFEB from WWP2-mediated ubiquitination & proteasomal degradation, thereby enhancing #lysosome activity and #autophagy flux. hubs.la/Q02MVnXT0

Coordination of force-generating #actin-based modules stabilizes and remodels membranes in vivo, say Marco Heydecker, Roberto Weigert and colleagues NCI Center for Cancer Research: hubs.la/Q02MbPng0 #Physiology #Cytoskeleton #Organelles

Image: Low dose of PERK inhibitor GSK’157 aggravates glucose intolerance in diet-induced #obsesity mice. Rai et al. Anne Bertolotti MRC Laboratory of Molecular Biology show that integrated stress response activator halofuginone protects mice from #diabetes-like phenotypes. hubs.ly/Q02Lz7Kb0

Chougule (Amit Chougule, PhD), Gardinier Henry Ford Health and colleagues demonstrate that osteocytes’ expression of P2Y2 mediates #actin polymerization and mitigates the anabolic response to fluid flow. hubs.la/Q02N9t9-0 #Cytoskeleton #CellSignaling

Image showing that LEM domain proteins and NE repair factors accumulate near nuclear polyQ aggregates. Korsten, Kapitein and colleagues Utrecht University show that nuclear poly-glutamine aggregates rupture the nuclear envelope and hinder its repair hubs.la/Q02Lz9Jd0

Our September issue is out! hubs.la/Q02N4zdK0 🔬 The cover shows the heart (cardiac tube) of a 20-day old adult #Drosophila stained with phalloidin (red), while adjacent pericardial cells are marked by dorothy-GFP (green). From Jayati Gera et al (hubs.la/Q02N4zxk0)

A TMEM24-4.1-SynCAM1 complex at sites of cell–cell contact. From Johnson et al. De Camilli Lab Yale Neuroscience identifying a mechanism that couples cell–cell adhesion to the formation of ER/PM junctions with lipid transport properties: hubs.la/Q02LK1yq0 #CellSignaling #Neuroscience

We are on the COVER 🤩🥳🥂✨️ Check out the September issue JCellBiol Rockefeller U. Press ✨️✨️ Sudip Mandal Lolitika Mandal DHEERAJ KR SINGH Gunjan Chauhan Adarsh Choudhary 🥂🥂

Near millimolar concentration of #nucleosomes in mitotic #chromosomes from late prometaphase into anaphase. New study from Fernanda Cisneros-Soberanis, Eva Simpson, William Earnshaw et al. WTCCB Cell Biology The University of Edinburgh: hubs.la/Q02MwXcG0 #CellDivision #StructuralBiology #Mitosis

Shout out to Shariq Ansari for having an image from his paper (green) featured on the TOC page of today's issue of JCB! By coincidence, Shariq took an EM selfie the day the image was acquired 🔬 Also shout out to colleague CC_Lab who has a paper in the same issue (blue)!

September issue of JCellBiol also contains our new paper on TLNRD1 (talin rod domain containing 1) protein and its role in the Cerebral Cavernous Malformation complex. rupress.org/jcb/article/22… Guillaume Jacquemet Inst of Systems, Molecular & Integrative Biology School of Biosciences, University of Kent Turun yliopisto - University of Turku

Aurora B controls anaphase onset and error-free chromosome segregation in #trypanosomes, say Daniel Ballmer, Bungo Akiyoshi @bungoakiyoshi.bsky.social Department of Biochemistry at Oxford University WTCCB Cell Biology and colleagues: hubs.la/Q02MV3gF0 #Microbiology #Genetics #CellDivision #kinetochores

Lactylation stabilizes TFEB to elevate #autophagy and lysosomal activity, say Yewei Huang, Gan Luo, Kesong Peng, Tianhua Zhou, Pintong Huang, Wei Liu and colleagues Zhejiang University: hubs.ly/Q02MVhfJ0 #Biochemistry #lysosomes

Model for the coordinated action of the two F-actin modules to control the integration of fused secretory granules. From a study by Heydecker, Weigert and colleagues NCI Center for Cancer Research: hubs.la/Q02MbNyS0 #actin #cytoskeleton

Purinergic signaling through the P2Y2 receptor regulates osteocytes' mechanosensitivity, say Amit Chougule (Amit Chougule, PhD), Joseph Gardinier Henry Ford Health and colleagues: hubs.la/Q02N9sX80 #Cytoskeleton #CellSignaling