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scTAM-seq, from Agostina Bianchi, Michael Scherer, Lars Velten, Renee Beekman & co is a high-throughput, targeted, bisulfite-free approach for single-cell DNA methylation profiling, that can handle up to 650 CpGs in 10,000 cells. genomebiology.biomedcentral.com/articles/10.11…

Cool new method for targeted single-cell methylome mapping by Lars Velten Renee Beekman labs - congrats to all authors!

Do you want to know more about scTAM-seq? genomebiology.biomedcentral.com/articles/10.11… . I will present our targeted DNA methylation profiling method at the Single-cell Multi-omics Symposium on Nov 3! Join in person or virtually.

Thank you Josep Carreras Leukaemia Research Institute (IJC) and Mission Bio for inviting me to present our recent published single-cell targeted DNA methylation profiling method 👉🏻genomebiology.biomedcentral.com/articles/10.11… Michael Scherer #singlecell #DNAmethylation #epigenetics

Last paper on single-cell DNA methylation analysis from the Velten and Beekman labs at the #CRG! Agostina Bianchi,Michael Scherer, Lars Velten Renee Beekman

For the last talk of this session, we have Agostina Bianchi from Renee Beekman explaining their exciting method to study DNA methylation in the single cell level “single cell method for detecting DNA methylation (scTAM-seq)” collab. with Lars Velten and Michael Scherer #CRGPhDSymp2022

If you are interested in #singlecell methylomes, consider the following webinar by Michael Scherer and Agostina Bianchi on Feb 23rd: missionbio.zoom.us/webinar/regist…

Nunca mejor explicado!

Looking forward to presenting at this webinar! Sign up below if you want to learn more. #DNAmethylation #singlecell #epigenetics

#ICYMI In this webinar, hear from Agostina Bianchi & Michael Scherer of Centre for Genomic Regulation (CRG) where they discuss the recently developed scTAM-seq protocol, which profiles 650 biologically relevant CpGs in up to 10,000 cells using the Tapestri platform! Watch on-demand👉 bit.ly/3ZvzWiF

Happy to see our manuscript out online today! (doi.org/10.1016/j.stem…) During the revision process we looked deeper at the stem cell compartment in AML as well as further assessed the validity of CloneTracer to identify healthy and malignant cells from scRNAseq (1/n)

You surely heard of X-chromosome inactivation. How about X-reactivation and X-upregulation though? It turns out that they all play together in the female mammalian germline. Check out how in our review by Tom Mattimoe from PayerLab Centre for Genomic Regulation (CRG) in Biochemical Journal 👇

Excited to finally share some of my PhD work on quantifying the effects of indel mutations on protein stability and function using deep mutational scanning. From sunny Centre for Genomic Regulation (CRG) together with Toni Beltran and guidance from Ben Lehner biorxiv.org/content/10.110…

Do you want to know about using DNA methylation to study cell identity, proliferation, genome activation history, or tumor cell of origin in single cells? Check out our review! frontiersin.org/articles/10.33… #DNAmethylation #SingleCell #hematopoiesis

This is the result of amazing scientific discussions with Leone Albinati and Renee Beekman

Don't miss this!! Open Junior #PI position in #GenomeBiology at CRG (Centre for Genomic Regulation (CRG)), feel free to PM me if you have any questions about the position, how it is to be Junior PI at CRG, or about life in Barcelona! :-)

Don’t miss our opinion article on DNA methylation, hematopoiesis and single-cell DNA methylation profiling methods! Read more in the thread below ⬇️

Nice overview of our recent opinion piece on DNA methylation and single cells!