1/6 Introducing MultiMIL: a weekly supervised multimodal model to identify disease-specific changes in single-cell atlases. Using a multiple-instance learning framework and attention mechanism, it prioritizes cells linked to various phenotypes in a large single-cell reference

HLA is the locus that everyone loves to hate, so it rarely gets invited to the GWAS party... There’s good reason for this. The region has extensive LD, high gene density and high polymorphism. (Thread + preprint link below ⬇️) (1/8)

Our first foray into spatial transcriptomics, in this case combined with phospho-Synuclein staining to identify factors that drive pathology in a transgenic mouse model biorxiv.org/content/10.110…

I'm excited to share that our new paper on modeling Alzheimer's disease was published today in Science Magazine . I'm extremely grateful for the tremendous support and guidance from my mentor, Dr. Andrew Yoo WashUDevBio WashU Center of Reg Med and fantastic coauthors.science.org/doi/10.1126/sc…,

A Sunday read for you. In this week's post, I write about tau protein in Alzheimer's and the recent preprint from D. Chloe Chung, PhD et al. on the "Big tau" and its impressive resistance to Alzheimer's pathology, hinting an exciting therapeutic path forward. gwasstories.com/p/the-big-tau-…

Challenging dogma on Alzheimer's disease and beta-amyloid production: the role of oligodendrocytes Now 2 reports journals.plos.org/plosbiology/ar… PLOS Biology Marc Aurel Busche Rikesh Rajani UK Dementia Research Institute UCL nature.com/articles/s4159… Nature Neuroscience Andrew Octavian Sasmita Klaus-Armin Nave

Congratulations to TatsuhikoNaito for receiving BrightFocus Foundation grant! His project titled “Decoding #Alzheimer’s Disease Genomes With Deep Learning”. Co-mentored with David A Knowles (@davidaknowles.bsky.social) #ADSP #AI #MachineLearning #LoebCenter Friedman Brain Institute Mount Sinai Genetics NY Genome Center

Our commentary (with Alex Sasse Alexander Sasse and Maria Chikina Maria Chikina ) on past and future of sequence-to-function deep genomics models is online Nature Methods : nature.com/articles/s4159… Along with many thoughtful Comment Articles online today: nature.com/nmeth/articles…

🧵 Excited to share my first preprint from my PhD Kipnis Lab and The Colonna Lab: "Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Identities from Microglia." 🧠🦴 biorxiv.org/content/10.110…

Generative AI, large language models, transformers, foundation models - what does it all mean and what is the potential impact on your research? Whether you're an AI novice or an AI expert, we invite you to read our Focus issue on advanced AI in biology. nature.com/nmeth/volumes/…

Sydney Brenner's scathing indictment of modern academia in an obituary for Fred Sanger: "We no longer have a culture that allows individuals to embark on long-term - and what would be considered today extremely risk - projects."

Very happy and proud to share our new Nature Medicine paper: comprehensive study of brain aging using our deep learning method, and its genetic, biomarker, clinical, and lifestyle correlates. Work that started in 2016! nature.com/articles/s4159… -->towards dimensional neuroimaging

Happy to share new results of SV association scans covering 20+ age-related clinical and neuropathologic traits! Suggestive findings in known AD GWAS loci and potential novel loci. doi.org/10.1101/2024.0… Full summary stats available on GitHub! #medRxiv #rushalzheimers #genetics

What causes PSP? Hadley Ressler's elegant new paper strongly supports evidence that 4Rtau mRNA synthesis going up is potentially a major driver: pubmed.ncbi.nlm.nih.gov/39154163/ Amazing work - congrats! #tau #psp The PSP Association Cure MAPT FTD CurePSP The Rainwater Charitable Foundation PSP Society of Canada Friedman Brain Institute

After precisely 4 years of grad school, I'm excited to share that the FIRST PEER REVIEWED PAPER FROM MY PHD HAS LANDED! cell.com/cell-systems/f… Indulge me in some back-story. 🧵

Spatial omics have lit up life science and this new review Cell is the best I've seen cell.com/cell/fulltext/… open-access

We've seen how plasma proteins can track brain aging and the factors that modulate it. Here's a new study using fMRI and EEG, with #AI, do that in over 5,300 participants in 15 countries. nature.com/articles/s4159… Nature Medicine

I had no idea how wild the story of human evolution was before chatting with the geneticist of ancient DNA David Reich. Human history has been again and again a story of one group figuring ‘something’ out, and then basically wiping everyone else out. From the tribe of 1k-10k

#MLCB2024 kicks off in 22h (9am PST) with keynote from Jian Zhou on DL for transcriptional initiation! Full schedule at mlcb.github.io and public livestream at youtube.com/live/reqWvNOKl…. Please RT!