THE CELL’S POWERHOUSE Mitochondria (yellow) make much of the chemical energy that fuels the life of a cells. They also move rapidly as seen in this cancer cell compared to the relatively slow moving nucleus (blue) and cellular adhesions (purple). #MitoMonday #CellBiology

THE ITACONATE PHENOTYPE!! breakthrough from @MoniBambouskova et al *LPS tolerizes WT macrophages to NLRP3 inflammasome BUT not Irg1-/- macs, they fully activate! *Endogenous ITA acts downstream of ASC affecting caspase-1/GSDMD *GSDMD-Cys77 is itaconated cell.com/cell-reports/f…

I'm happy to share that out paper on Phantasus, a web-application for visual and interactive gene expression analysis, got out in eLife - the journal elifesciences.org/articles/85722 Here, I'm using it to analyze a random GEO dataset, including basic QC to filter outliers, in under 100 seconds! 1/n

latest from our lab: ITACONATE MECHANISM SOLVED!! Tom Paulenda Tomas Paulenda solved molecular mechanism of immunoregulatory action of itaconate in macrophages: nature.com/articles/s4225… Previously, our lab has discovered two major immunoregulatory phenotypes of itaconate in

Together with Maxim Artyomov, we wrote a short blog post with the backstory of our itaconate-Prdx5 discovery. It allows a glimpse into how the story evolved over time and how we got here. communities.springernature.com/posts/itaconat…

I’m excited to be speaking at IMMUNOLOGY2025™! You can find me at BLOCK SYMPOSIUM: INM3 - Cellular and Molecular Mechanisms of Innate Immunity DATE:5/4/2025 PRESENTATION TIME: 8:45-9:00 AM ROOM: Room 313B #AAI2025 #itaconate

I'm happy to present our new web-tool CORESH alserglab.wustl.edu/coresh/ for searching public gene expression datasets using gene signature as a query, developed by Vladimir Sukhov, which was just published in @NAR_open doi.org/10.1093/nar/gk… 1/n

Our RAPPL purification of ribosomes and associated material is finally out. I am really proud of this study in collaboration primary with slavica pavlovic djuranovic lab, as well as Marko Jovanovic and Yaser Hashem Labs. This method aims to replace 60 years old purification of ribosomes by