Additionally, while in a superiority design an intention-to-treat analysis is usually the most conservative approach, this is often not the case in a non-inferiority trial - here a per-protocol analysis is usually more conservative. Both should show non-inferiority 6/8

The CCR tradition continues..... #CCRdownunder faculty day out on the Mornington Peninsula #arthursseat INTENSIVE - The Alfred ICU

Honoured to join a remarkable meeting with brilliant faculties at #CCRdownunder in Melbourne. Days filled with respect for clinical trials and thorough discussions on critical aspects. "I am the dumbest person in the room, and it should be." Thank you Critical Care Reviews

The Mega-ROX is getting there. Total enrolments as of right now 30784 out of 40000.

Last publication in 2024🍾 We assessed the effects of non-adrenergic vasopressors in three populations (sepsis, cardiac surgery, and non-cardiac surgery). Our findings justify future RCTs comparing these agents with usual care based on noradrenaline alone. ccforum.biomedcentral.com/articles/10.11…

Shedding its skin, a natural process, symbolising rebirth and transformation. #Year2025 #ccrdownunder Critical Care Reviews Chris Nickson @precordialthump.bsky.social

❤️Family and Friends ❤️❤️❤️ Sometimes all you need in the ICU is to open the doors Be kind, be patient, be honest Welcome families to rounds Change the 🌎 for patients Elie Azoulay Jean-Louis Vincent Glorie Rodriguez-Vega,MD, FACP, FCCP, FNCS, MCCM Karin Amrein tomoko.fujii Frank van Haren Cherylee WJ Chang ISICEM #ISICEM25

#𝐈𝐒𝐈𝐂𝐄𝐌𝟐𝟓 – 𝐓𝐡𝐚𝐧𝐤 𝐘𝐨𝐮! An incredible few days of learning, collaboration & innovation! Huge thanks to our attendees, speakers & partners—your dedication is inspiring. The story continues… See you at #ISICEM26 or our next meetings! #ICUcommunity #ISICEMers

慈恵ICUは今年度、内科、救急、麻酔それぞれの経路から集中治療を志す新しいメンバーが増え、多彩（才）なチームとなりました。来週から新年度ですね。より豊かな1年になりますように。

Just one of those Japanese who feels obliged to inform the world that the cherry blossoms are in full bloom. #sakura #cherry_blossoms

A major update to the CONSORT reporting guidance for clinical trials was published last week. 📌 CONSORT 2025 replaces all previous versions and should be used from now on. So what’s new and what’s different? 1/7 #MethodologyMonday #116 (COI - I am a co-author)

In memory of Professor Rinaldo Bellomo 心からの感謝を込めて youtu.be/wWr6ePQZ_wg?si…

📚 Explore the first core Critical Care Data Dictionary (C2D2) to characterize critical illness and injury, available now in the May issue of CCM: bit.ly/4d8fnk2 #SCCM #CritCareMed SCCM

In memory of professor Rinaldo Bellomo: A giant of intensive care medi... sciencedirect.com/science/articl…

"The history of science is that everything is open to challenge. Everything that we believe today is not quite right." "You must never believe anything, especially the things you believe in." (RB)

Truly a pleasure to listen to such a brilliant mind :) Thank you, Kosuke Inoue pmc.ncbi.nlm.nih.gov/articles/PMC10…

We often now hear the term “Bayesian borrowing” in trials. But what is Bayesian borrowing and what are the pros and cons around its use? 1/6 #MethodologyMonday #122

Dissociation between SaO2 (ABG) and SpO2 (pulse oximetry) in East-Asian critically ill patients and its association with mortality. 📰available from CHEST® Journal sciencedirect.com/science/articl…

BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

The September issue of Critical Care and Resuscitation is now online. An entire issue dedicated to the extraordinary legacy of Rinaldo Bellomo: sciencedirect.com/journal/critic…