Tomas Fiala
@tomfialab
Senior Scientist and Branco Weiss Fellow at ETH Zürich | Supramolecular Chemistry and Chemical Biology
ID: 1444558227501428738
https://wennemers.ethz.ch/the-group/people/tomasfiala.html 03-10-2021 07:01:47
179 Tweet
353 Followers
381 Following
TWeeP (This Week's Paper): A cool new tool from the Bernardes lab—non-metallic carbon monoxide-releasing prodrugs. Tertiary aldehydes release CO after a radical trigger. A big step towards mapping out the therapeutic effects of CO. Now out in J. Am. Chem. Soc.. pubs.acs.org/doi/10.1021/ja…
TWeeP (This Week's Paper): Cool supramolecular chemistry of bambusuril macrocycles! In Chemical Communications, Heck et al. show strong complexation of the astatide-211 anion. The complex is stable in human serum! Nice progress towards At-based radiopharmaceuticals. pubs.rsc.org/en/Content/Art…
TWeeP (This Week's Paper): another fantastic publication from the Kanai lab in J. Am. Chem. Soc.. Check out how to generate isocyanates on demand from a stable hydroxamic acid–pyrrolidine conjugate and sulfonyl fluoride for fast protein labeling in live cells! pubs.acs.org/doi/10.1021/ja…
TWeeP (This Week's Paper): Hemes are ubiquitous in nature. Yet, their trafficking and dynamics remain underexplored. That's about to change thanks to probes that label neighboring proteins upon heme activation by Hirayama, Hideko Nagasawa and co. in J. Am. Chem. Soc.! pubs.acs.org/doi/full/10.10…
TWeeP (This Week's Paper): As a fan of looking at (bio)organic reactions from a physico-chemical perspective, I like the perspective by Schreiner and coworkers on the role of London dispersion forces in catalytic reactions. Check it out now in J. Am. Chem. Soc.! pubs.acs.org/doi/10.1021/ja…
TWeeP (This Week's Paper): PROTACs and other chemical dimerizers are based on non-inhibitory ligands which are hard to come by. The Kodadek lab presents a clever assay for mining such binders using one bead–one compound libraries. Now out in J. Am. Chem. Soc.! pubs.acs.org/doi/10.1021/ja…
TWeeP (This Week's Paper): Bulky amino acids are difficult to incorporate into peptides by SPPS. How about helping them out with induced proximity? Wei et al. do exactly that with their ribosome-inspired acyl-transfer linkers. Now out in Nature Chemistry! nature.com/articles/s4155…
⭐🎉 Přinášíme skvělou zprávu a další obrovský úspěch! Tomáš Fiala, držitel Start-up grantu Nadace Experientia, získal prestižní ERC Starting grant pro mladé vědce! Svoji výzkumnou skupinu založí v říjnu 2025 na MUNI Science. Tomášovi k tomuto úspěchu srdečně gratulujeme! 👏
Grant alert!🚨I am honored to receive the European Research Council (ERC) Starting Grant. In the PROTEOFORMER project, we will develop chemical tools for precise control of individual protein states, aiming to probe the origins of neurodegeneration.🧪Stay tuned! #ERCStG erc.europa.eu/news-events/ne…
TWeeP (This Week's Paper): The PTM sulfotyrosine (sTyr) is very hard to reliably identify due to instability and similarity to phosphoTyr. This week, I highlight a vivid debate in Nature Chemical Biology about the existence of sTyr in histones: nature.com/articles/s4158… nature.com/articles/s4158…
Minulý čtvrtek jsme slavnostně podepsali smlouvu o start-up grantu Nadace Experientia spolu s rektorem Masarykova univerzita Martinem Barešem a držitelem start-up grantu Tomášem Fialou. Se svojí výzkumnou skupinou bude studovat vznik neurodegenerativních onemocnění.
Skvělá zpráva ze světa chemie! 🌟 Mezi projekty JUNIOR STAR podpořené Grantovou agenturou ČR patří i projekt našeho držitele start-up grantu Tomáše Fialy z Masaryk University. Jsme hrdí a moc gratulujeme! 👏
I'm humbled to receive the Alfred Bader Award for Bioorganic chemistry and give a plenary lecture at the wonderful Liblice 2025 conference! Thanks to the Czech Chemical Society and to Bader Philanthropies for the honor!
