Ceramide Synthase 6 (CerS6) uses a ping-pong reaction mechanism! Found and probed via CryoEM, MD, and MS. Spectacular work by Tomas Pascoa and colleagues from Centre for Medicines Discovery, Boehringer Ingelheim (Boehringer Ingelheim), and University of Zurich biorxiv.org/cgi/content/sh…

The paper is now online in its revised form Nature Methods: nature.com/articles/s4159… . Many thanks to the anonymous reviewers and Rita Strack for the nice review experience. And shoutout to twitterless Oda, JP, and Christoph Kaiser! It has been a fun journey. 🥳🥳🥳🥳🎉

It’s only day 1 of 2024 and the UK is already in full pathetic farce mode. Slow down guys, it’s a marathon, not a sprint to rock bottom

"Integrating cellular electron microscopy with multimodal data to explore biology across space and time"🔬👩‍💻🌌⏳ cell.com/cell/fulltext/… Our new review is online Cell. Big thanks to our amazing co-authors @computingCaitie Sven Klumpe Rommie Amaro Wanda Kukulski @EM_STP

The molecule of the month is HDCR! :) nature.com/articles/s4158…

It was truly a pleasure hosting a #TeamTomo hackathon at the Biozentrum, University of Basel with Kyle Harrington Kevin Yamauchi Lorenzo Gaifas Lorenz Lamm Daniil & Ricardo. The result of your awesome jam: Surforama🏄‍♀️. Now it's possible to make "membranograms" and pick particles in napari #OpenSource🔬💻

Check out our preprint on redox-coupled sodium pumping of the ancient Rnf machinery. Great collaboration with SchullerJM and Müller Labs. doi.org/10.1101/2024.0…

"2D template matching is wonderful" And #EMBOCryoEM was incredible!

#EMBOCryoEM was an amazing course!

Really happy to share that the last chapter of my submitted phd thesis is already on biorxiv!🥳 Using a tophat transform, I made template matching more precise, allowing automated annotation with little false positives! #teamtomo biorxiv.org/content/10.110…

Proud to announce that #ONE_microscopy is now published in Nature Biotechnology. We now reveal that ONE enables the 3D reconstruction of single protein molecules from light microscopy. More here: nature.com/articles/s4158… Silvio and I extend our immense gratitude to our collaborators

After thousands of microscope hours and several years of painstaking optimisation, Callie Glynn and I are very excited to share our latest manuscript. We outline our approach to investigate the molecular organisation within hippocampus tissue using cryo-ET.

Really nice to see Nuffield Department of Medicine highlighting our research and the value of partnerships between academia and industry!