Our preprint is live! Thanks to everyone who helped me learn how to study gene regulation so we can investigate rAAV processing 💪🏼

Congrats Thomas Graham and all the amazing Berkeley MCB postdocs! You rock!👏

Awesome day of science at the Physics of Life 2023 Symposium hosted by Chan Zuckerberg Biohub Network - great to catch up with our biophysics colleagues across the Bay!

Applications are open for HHMI | Janelia’s spring conferences — small meetings that foster conversation, collaboration, and inspiration. No registration fees Hotel + meals covered Travel support and child care available Apply at bit.ly/spr24confs

Best wishes to our amazing postdoc Liza Dahal who is on to her next step! 🎉☕️

Check out our latest work on PRC2 and its inhibition by active transcription histone posttranslational modifications led by Trinity Cookis and work from twitterless undergraduate Alexandria Lydecker, @paulvictorsauer, and Vignesh Kasinath biorxiv.org/content/10.110…

New study on #transcription regulation in human #placenta development - we find that the transcription factor #TFEB is required for the differentiation of a fusing cell type in the placenta (syncytiotrophoblasts) by controlling cell-cell fusion! biorxiv.org/content/10.110… 🧵

This is a very cool paper and (potentially) highlights similar mechanistic pathways underlying cell-cell fusion in multiple human syncytia (placenta, bone, skeletal muscle):

Excited to share the first manuscript of my postdoctoral work in the Tjian + Darzacq Group lab UC Berkeley MCB: “Automated live-cell single-molecule tracking in enteroid monolayers reveals transcription factor dynamics probing lineage-determining function” biorxiv.org/content/10.110…

(1/7) We’re excited to present a new manuscript in which we’ve applied proximity-assisted photoactivation (PAPA) to monitor subunit interactions within endogenous transcriptional regulatory complexes in live cells: bit.ly/ptefb_papa

I am super excited to be running the Cal Women in Imaging Bootcamp again this year! If you missed us last time, sign up now - it's such a fun way to build community at the beginning of grad school and learn more about microscopes and careers along the way! 🔬👩‍🔬🌈 Link below 👇

Deadline is coming up (August 14) to submit an abstract for the Single Biomolecules meeting in Cold Spring Harbour. Looking forward to this meeting where biology meets imaging technologies. meetings.cshl.edu/meetings.aspx?…

We were certainly surprised to find that in human #placental cells the TF #TFEB does NOT control #lysosome gene expr. but instead regulates the expr. of Syncytins to control cell-cell fusion! Excited to see my work now (officially) published Genes & Development 👉m.genesdev.cshlp.org/content/early/…

So cool to see Thomas Graham’s work featured in the nature Briefing today! Read more about our developments to detect single molecule protein-protein interactions in live cells here : nature.com/articles/d4158…

In this study, Esbin et al. report a critical new role for the transcription factor TFEB in controlling fusogen expression and syncytiotrophoblast fusion during placental development. Meagan Esbin Tjian + Darzacq Group Learn more here: ➡️ tinyurl.com/gd351633

I am excited to share the first publication from my postdoc Tjian + Darzacq Group lab UC Berkeley MCB: “Automated live-cell single-molecule tracking in enteroid monolayers reveals transcription factor dynamics probing lineage-determining function” Cell Reports cell.com/cell-reports/f…