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Matt Kaeberlein giving his opinion on direct to consumer biological ageing tests and the ageing field in general. Definitely worth a watch. The Truth About Biological Age Tests youtu.be/8mlRkXZFvi8?si… via YouTube

Excited to share ‘Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins’, by phenomenal superstar postdoc Aakriti Jain Aakriti Jain and amazing collaborators Rushika M. Perera, Guido Bommer, Charly Craik and James Olzmann: science.org/doi/10.1126/sc…

"Just as physical exercise stresses the body to build stronger muscles, a controlled mild stress to #lysosomes could boost resilience and improve health outcomes across the #lifespan." nature.com/articles/s4155…

Meet Romulus and Remus—the first animals ever resurrected from extinction. The dire wolf, lost to history over 10,000 years ago, has returned. Reborn on October 1, 2024, these remarkable pups were brought back to life using ancient DNA extracted from fossilized remains. Watch

I've dreamed of this since Jurassic Park came out

Check out our latest Comment in Nature Cell Biology on #autophagy (how cells of your body recycle damaged material). While declining autophagy is often seen as a hallmark of #ageing, we explore emerging exceptions to this idea. SAHMRI Uni of Adelaide nature.com/articles/s4155…

Does autophagy really decline with ageing? What can LC3-based measurements truly tell us about autophagy? And how can we bridge the gap between preclinical findings and human biology? We explore these questions in our latest comment in Nature Cell Biology: bit.ly/4cjOSHU

In our recent Nature Cell Biology comment, we highlight mounting evidence that —contrary to dogma— #autophagy doesn’t always decline with age.. in fact, it often increases! Sanjna Singh Assoc. Prof. Tim Sargeant SAHMRI The Hospital Research Foundation Group nature.com/articles/s4155…

We can't work out why funds designated to medical research can't be released from the MRFF. Not new debt, current funds. So we animated it 👇. Share this, tag in your MPs, and help AAMRI secure the election promise that the unspent funds, that are allocated and available, will be

Beyond the Hallmarks: What are we missing in ageing research? At the Global Conference on Gerophysics 2025, I posed several uncomfortable—but necessary—questions: 🔹 Why haven't we don better than caloric restriction for lifespan extension in mammals—after 50 years? 🔹 Have

New study: we measured autophagic flux in human blood and compare intermittent fasting with calorie restriction = the largest human autophagy study to date. Although significant, changes in autophagy were modest. #autophagy #fasting #aging SAHMRI physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

NEW STUDY: It's dogma that fasting is good for you because it increases autophagy, the recycling of cell parts. But in the largest study ever, 6 months of time-restricted eating (TRE) or calorie restriction (CR) did not increase autophagy Huh? Is fasting still worth it? ... 🧵

In a recent study published by our group, we measured autophagic flux in human PBMCs. We cannot yet measure #autophagy in organs, which is why we are developing tissue specific autophagy biomarkers.

Crucial new pilot study to investigate whether #rapamycin can be used against dementia causing diseases published yesterday. nature.com/articles/s4385…

I'm looking forward to attending the 11th International Symposium on #Autophagy. The last one in Sapporo, Japan was a great meeting and that is set to continue in Lorne, Victoria, in November of this year. Early bird rego closes August 29 here: isa11.org #isa11

Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025! 📍 Location: Lorne, Victoria, Australia 🌐 Register now: isa11.org Join us for five inspiring days of cutting-edge autophagy research!

A/Prof Assoc. Prof. Tim Sargeant is the latest guest to feature on the Community Conversations podcast. 🎙️ A/Prof Sargeant discusses all things autophagy - the latest research, tips for optimising cellular health and more! Listen 🎧 sahmri.au/CC-Tim-Sargeant

Sunrise from SAHMRI with the Adelaide Oval and St Peter's Cathedral

Our paper about how autophagy changes in mice as they age is now available at PLOS One ! Big thanks to Assoc. Prof. Tim Sargeant , Brad Turner & team, as well as SAHMRI , @uniofadelaide & The Hospital Research Foundation Group ! journals.plos.org/plosone/articl…

New research paper on human #autophagy from our group at SAHMRI. Dr Linh Dang analysed autophagic flux with cell type specificity. We show data important for designing clinical trials for human autophagy - cell type matters: faseb.onlinelibrary.wiley.com/doi/10.1096/fj… #aging