Our new ms “Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain” is now at nature . rdcu.be/dEmgT! We report on human forebrain dynamic assembly during development…1/n

We are all walking mosaics of genetically distinct cells. Every cell acquires around one mutation each division after fertilization, resulting in a vast amount of genetic diversity across all the cells in our bodies by the time we are born.

Interested in studying somatic evolution and cancer risk across species? Mathieu Giraudeau and I have a 2 year post doc opportunity to explore this area. See below for more details.

Plenary by Tim Coorens on the somatic mutation landscape of normal gastric epithelium #MITS24

Interested in doing a PhD on somatic evolution in plants? Max Brown 🌱 at ARU_Biology and I will be co-supervising a 3-year PhD studentship starting September 2024. More details on the position and how to apply here: findaphd.com/phds/project/s…

Taking a pancreatic tumor for a spin using CODA. Using the AI-based CODA workflow, we map a pancreatic tumor and its microenvironment at single-cell resolution. Key advantages: 3D, huge sample volume, multiple labels, easy multiplexing, single-cell. nature.com/articles/s4158…

"Tempora mutantur, et nos mutamur in illis". Ovid knew long ago that our somatic genomes evolve throughout life... Super excited to share our new paper on connecting clonal outgrowth in somatic evolution with epigenetic profiles nature Open here: rdcu.be/dHkeS 🪡

What is the origin of our body? Our paper Cell shows that when a human embryo is one day old and comprises just two cells, only one cell will create most of the fetus in addition to placenta, while the other cell will create placenta. cell.com/cell/fulltext/…

Delighted to have this paper out in Nature Genetics ! We found a bunch of additional genes driving clonal expansions in blood as we age. Time to update those panels! Still only halfway there though... doi.org/10.1038/s41588… Brief X-plainer below

New pre-print from our lab, with our amazing collaborator Daniel Orringer and his team. We introduce Ultra-Rapid ddPCR. It can quantify mosaicism of somatic mutations from tissue to result in < 15 mins, fast enough to guide tumor resection surgeries. medrxiv.org/content/10.110… 1/5

New out in Nature!! With age, women can lose one X chromosome in their leukocytes. What’s the cause/consequence? How does it differ from the loss of the Y chromosome in men? nature.com/articles/s4158… Broad Institute FinnGen FIMM HelsinkiUni National Cancer Institute Cambridge University

🎉New paper🎉Introducing #StrandInteractions, the sequel to #LesionSegregation, published today nature Strand-resolved mutagenicity of DNA damage and repair nature.com/articles/s4158… Here’s what we discovered about (a)symmetry in replication, transcription & #mutagenicNER [1/13]

Now out nature, our paper on HiDEF-seq: single-molecule DNA sequencing that resolves single-strand changes (mismatches and damage)! go.nature.com/3KG7Njh

I’m thrilled to shared that this August I’ll join the Department of Pathology of the University of Cambridge Cambridge University as a Group Leader. The Machado Lab will study the somatic evolution of the adaptive immune system to understand aging and disease.

How do healthy tissues evolve to become cancerous? Delighted to share our latest research tracking the somatic evolution that occurs in the decades before AML. 👇Implications for early detection and early interception. biorxiv.org/cgi/content/sh…

New deadline: Sept. 15! 2 year post doc opportunity in comparative oncology, cancer resistance and somatic mutation rate with Alex Cagan and Mathieu Giraudeau Orsolya Vincze Widlife Cancer Evolution Research Group (WiCanE) more info here: euraxess.ec.europa.eu/jobs/228103 (UMR LIENSs CNRS Écologie & Environnement )

Fun article about our ongoing adventures investigating somatic evolution across species Cambridge University cam.ac.uk/stories/dr-ale…

Join us! The Machado Lab at Cambridge University is looking for an enthusiastic RA to be a core member of the team and lead the lab's data generation efforts, seeking to understand how tumour and immune cells co-evolve and contribute to cancer progression. jobs.cam.ac.uk/job/47922/

🦍Postdoc in Somatic Evolutionary Genomics🦍 Join my team GeneticsCambridge on a pioneering project mapping somatic mutations across primates! 🌍Collaborate with experts UC Berkeley & Wellcome Sanger Institute. 🔍Experience in genomics? Apply by Nov 16! Details: jobs.cam.ac.uk/job/48757/

PhD and Postdoc positions available! Interested in how our immune system evolves with a growing tumour, and how we can use that to fight cancer? Love data analysis? Applications now being accepted in the Machado Lab (machado-lab.org/contact) at the University of Cambridge.