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CD3, bone marrow biopsy after treatment with JNJ bispecific antibody. Showing the T cells recruited in action. There is still a minute residual disease though (about 2-3% lambda restricted PCs) 😌

13 yo boy, enlarged axillary lymph node. Spot diagnosis 😉 What is the IPOX stain?

Lymph node, a patient with Sezary syndrome. DL and RFH. But look at the beautiful CMC (cerebriform mononuclear cells) on high power. Decreased CD7 expression and clonal TCR rearrangement. Peripheral blood flow showed 40% CD4+/CD7- cells and 40% CD4+/CD26- cells.

ICCS has revitalized their YouTube channel and will be releasing a range of #flowcytometry videos for all levels, from beginners to experts. The first video is on tandem dyes: youtube.com/watch?v=5cV7E9… Be sure to like and *subscribe* so that you don't miss new videos! #hemepath

2.5 yo boy with known PTPN11 mutated JMML (germline). Now presenting with rapid increase of WBCs. BM Flow showed 13% CD34 positive blasts. But on the aspirate smear it seemed much more. Take a look at the IRF8 IHC vs CD34 (same area for comparison). IRF8 😍💪🏻