Did you know there are lots of similarities between the innate immune systems of animals/plants and the phage defense systems in bacteria? Check out our new study by the amazing trio Alex (Linyi) Gao, Max Wilkinson, and Jonathan Strecker. Congratulations! science.org/doi/abs/10.112….

🚨New chemical tools for SARM1!🚨 Very excited to see our work published today in PNASNews detailing the chemoproteomic discovery of stereoselective/site-specific allosteric #SARM1 inhibitors. Huge thanks to #LLJRC, Andrea Loreto, and all co-authors! pnas.org/doi/epdf/10.10…

Happy to share our cADPR paper out today @Science: science.org/doi/10.1126/sc… A wonderful collaboration between Kobe Lab, Milbrandt & DiAntonio @WUSTL, Ming Guo, @Muzzapythopath and us Griffith University's Institute for Glycomics Congratulations Mohammad Kawsar Manik, Yun Shi, Sulin Li and all co-authors!

Fantastic new work led by QPG stalwarts Kobe Lab and Thomas Ve and many amazing Queensland protein scientists. science.org/doi/10.1126/sc…

Released today EMDB - EMPIAR @EBI & Protein Data Bank, & published Science Magazine, #CryoEM structure of the Toll/interleukin-1 receptor domain from #AbTir in complex with 3AD. Study by Mohammad K. Manik et al., @ 2.74 Å resolution.

Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease Sea cell.com/neuron/fulltex…

We made #AlphaFold dream of new protein assemblies, used #ProteinMPNN to bring it back to reality, and the results were stunning! (1/5) science.org/doi/10.1126/sc…

Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products biorxiv.org/content/10.110…

The Kranzusch lab (kranzuschlab.med.harvard.edu) and Sorek lab Sorek Lab report discovery of gcADPRs as a new class of antiviral signals. @nature nature.com/articles/s4158…

It's on again in 2022! The Ross Smith ECR Medal Symposium this year will be held on 15th November at the Glycomics Institute, Griffith University. Please apply for either ECR or student prizes and look forward to seeing you there! eventbrite.com.au/e/2022-ross-sm…

Out today Cell Host & Microbe: An expanded arsenal of bacterial immune systems Even if you previously read the preprint, don’t miss a major new result on the bacterial SEFIR domain, a homolog of human immune domains A thread 🧵 1/9 sciencedirect.com/science/articl…

2 new papers in JCI from the DiAntonio/Milbrandt labs shed new light on Sarm1’s role in neurodegeneration. 1)Chronic Sarm1 activation leads to macrophage recruitment that plays a role in axon degeneration. 2)Eliminating Sarm1 slowed AXD in a model of CMT. tinyurl.com/27f5udjm

Dear QPG members. Please vote for your new QPG executive, Treasurer, Secretary and Website coordinator! surveymonkey.com/r/RV276PP

So excited that we finally have the ACTIVE NLRP3 inflammasome structure, thanks to super talented Le Xiao Le Xiao, and Venkat Magupalli Venkat Giri Magupalli! nature.com/articles/s4158…

Excited to share our preprint on using unsupervised learning to find inhibitors from fragments hits. The idea is learning a distance distribution of pharmacophores from fragment hits, and then scoring a large purchasable library using that. (1/3) biorxiv.org/content/10.110…

Dear QPG member, the deadline is coming up soon, get your abstract and CV ready for an exciting opportunity to speak at ASBMB 2023 and get your registration costs covered by QPG.

Did you know that bacterial #viruses glue #RNA to proteins? We discovered that a T4 #phage #ART links NAD-RNA to E. coli proteins. We call this an #RNAylation. Great collaboration with Jaeschke Lab and Urlaub Lab. Congratulations to Maik Wolfram-Schauerte 🍾 nature.com/articles/s4158…

QPG would like to announce the 2023 Queensland Protein Group and Ross Smith ECR Award Symposium will be held on Tuesday 17th October at the Queensland Brain Institute from 1 – 5pm followed by a mixer and presentation of the awards (see attached flyer for more information).

Congrats Bronwyn Griffin & Dr Yun Shi on your NHMRC grants! A/Prof Griffin's work on early intervention strategy for kids with burns & Dr Shi will study brain biomolecule that protects nerve cells in neurodegenerative disorders Griffith University's Institute for Glycomics Griffith Health news.griffith.edu.au/2024/05/02/gri…

ECPM2024 registration is now open eventbrite.co.uk/e/east-coast-p… Award opportunities for student and postdocs: Best talk and poster presentations awards Student travel awards Early career researcher (<5 years post PhD) can be considered for the BioMolecular Horizons (BMH)2024 award.