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Just learned that humanity is now building neuron-silica biohybrid materials to integrate into brains. Science fiction -> science fact science.xyz/news/biohybrid…

Biggest GWAS to date on MDD. Take homes: 95% of MDD risk comes from envt (!); glial cells likely have little role; MDD is not a NDD; D2R modulators may be a good approach for future research. Most samples from those of European decent.

This is the future of genotype-to-phenotype mapping. Actually testing the effects of variants on function. Great summary, and can't wait to read the paper!

One thing I never understood about biomarker prediction of psychiatric med response was - why don't we do it more? Turns out it's because it doesn't really work that well with what we have so far

Novel sodium-channel inhibitor as effective as an opioid, approved by U.S. FDA Vertex Pharmaceuticals The land-and-expand approach already has multiple fast-followers for sodium channel blockade of Na v1.7 and v1.8 - exciting times ahead, especially excited for chronic pain

In the ED, we give migraine cocktails (part of which includes an NSAID) and sometimes a triptan for migraine abortion. Auvelity, Cobenfy, Carbidopa/Levodopa and now Symbravo - the utility of combination therapies in neuroscience and psychiatry is just beginning

Even in silico neurons benefit from having biologically inspired architectures - super cool, there’s still so much to learn from evolved systems

All 5 nucleobases, 14/20 amino acids at near equimolar fraction of right and left handedness found on asteroid Bennu I think the scientific term for this is “we are not alone” 👀

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Why outcomes matter. 1. 2023 meta-analysis on bipolar depression showed Lithium failed to reduce depressive symptoms 2. Yet, recent 2025 meta-analysis finds Lithium as the only treatment to successfully reduce depression-related hospitalizations The first study measures

Interesting argument as to why measuring all neurons simultaneously still does not guarantee a map of firing to function.

Gene set enrichment analysis gets a makeover! The GO terms we all love now have integrated phylogenetic evolutionary information to provide as close to biological function as we’ve ever gotten for each gene

Interesting study that supports combination brexpiprazole and sertraline for PTSD, supporting a recent study published in JAMA Psychiatry just a few months ago. Big caveat: trial validity is questionable because brexpiprazole or sertraline alone did NOT separate from placebo

Speaking in overarching generalities, I think there's a huge bias in academia that looks at industry and says "we do all the innovation, y'all just do production". This looks pretty innovative to me. Rather than change the sequencing technology, change DNA itself 🤯

Wow this truly never gets old. Humans went from being a land-only species to reusable space flight in 120 years. That is less than the blink of a blink of an eye in evolutionary time.

Our paper, co-led by the brilliant Nathan Huneke and Guilherme F Veronesi from University of Southampton , out in JAMA Psychiatry . Everything you wanted to know on #placebo, #blinding, and #expectation effects in #psychiatry but you never dared to ask! jamanetwork.com/journals/jamap…

capitalism is humanity’s greatest invention

This is extremely forward-thinking, and time will tell if premature. But one thing is for sure - this is a boon for drug discovery.