Dan Peiffer
@theproffermd
Hem/Onc Fellow @Uchicagomed PSDP| Aspiring Physician-scientist interested in breast oncology, cancer stem cells and tumor immunology | Opinions my own
ID: 1178709227805777921
30-09-2019 16:32:45
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Today we observed the coagulation lab firing on all cylinders. Mixing studies are helpful for diagnosing the lack of coag factors, which will cause a patient’s PT to decrease when mixed with normal serum. Kamran Mirza MD PhD - کامران مرزا #pathology #pathelective
Well known to be critical for organ transplants, HLA typing is also crucial for new cancer therapies that employ adoptive T-cell transfer as some TCRs are HLA-restricted. Thus, only patients w/ a specific HLA will reap the anti-cancer benefits. Kamran Mirza MD PhD - کامران مرزا #pathology #twitterhomework
APL is characterized by the accumulation of granulocytes and promyelocytes with the presence of Auer rods. Diagnosis is made via FISH indicating a 15;17 translocation with quick initiation of all-trans retinoic acid to avoid the development of DIC. Kamran Mirza MD PhD - کامران مرزا #pathology
AML is associated with a particularly poor prognosis with up to 40% having refractory disease. This is thought to be due, in part, to the high degree of heterogeneity within the disease as well as the persistence of cancer stem cells within the population. Kamran Mirza MD PhD - کامران مرزا #pathology
Basophilic stippling of RBCs is characterized by basophilic granules made up of RNA and/or ribosomal proteins. They can be seen in variety of disorders including thalassemia, severe macrocytic anemia, and lead poisoning. Kamran Mirza MD PhD - کامران مرزا #pathology #pathelective #twitterhomework
Research from the Rosner lab shows that low doses of a four-drug combination help prevent the spread of cancer in mice without triggering drug resistance or recurrence. #AnswerCancer ow.ly/jalq50F54Yr eLife - the journal
What is the cost/utility of routine T&S in minimally invasive hysterectomy? Is it needed? ➡️ Anne Tjaden Peiffer, MD found that Hgb < 10.6🩸predicts need for transfusion #SGS2021 Thythy Pham, MD Nicolette Codispoti, MD, MS, MPH @LUMCObGyn
The largest study to date (N=1.13M❗️) on the prognostic value of HER2-low expression is out on JAMA Oncology. With an HR 0.98 & overlapping OS curves, HER2-low confirms not to be a relevant predictor of prognosis. Congrats to the authors for this huge analysis! jamanetwork.com/journals/jamao…