Are your cells mature? Does it matter? In our latest Cell, we review Cell maturation: Hallmarks, triggers, and manipulation. We discuss a new framework, based on cell plasticity, to understand how cells become specialized.. UPenn CDB Institute for Regenerative Medicine authors.elsevier.com/c/1eNDXL7PXf0d…

“Meet the Scientist: Douglas Melton” on vimeo.com/442134935/9f56… special thanks to @JDRF and The Melton Lab team! HSCRB

“The promising results we’ve seen with #stemcell-derived islet cells could deliver a life-changing therapy for people who suffer from the relentless life-long burden of #Type1diabetes," said Dr. Douglas Melton, co-director of HSCI Institute.

Diabetes cell therapies take evasive action - Elie Dolgin go.nature.com/3hn0P42

🔬Today in StemCellReports, research from Nayara Leite, Douglas Melton & colleagues has identified new ways to enhance the SC-beta cell survivability through genetic manipulation of the cells. Read on 👉 bit.ly/3CeeAeR. Image: The Foundry. Martin Pera The Melton Lab

👨‍🔬Hear abt Doug Melton's latest work developing #stemcell therapies for #diabetes @ our Jerusalem symposium. His pioneering work deriving insulin-producing beta islets cells from PSCs led to the 1st in-human clinical trial ow.ly/7FAe50Im00X HSCRB HSCI Harvard University

It was a pleasure to participate with The Melton Lab on the StemCellReports podcast. Thank you for having me!

Probably the last time together with these outstanding people and outstanding mentor. Thank you The Melton Lab

⏰ Don't miss the opportunity to hear groundbreaking research & to network with this impressive line-up of past #ISSCR presidents at the #ISSCR2022 Annual Meeting 15-18 June in San Francisco. Register by 11:59 EDT 13 April for the best rates 👉 ow.ly/oLJM50IJcqW

This is just one of many good things that might happen when you listen to the Stem Cell Report. Hear more from Doug Melton The Melton Lab & Nayara Leite at bit.ly/3rqVhea & read their recent paper, bit.ly/3EkcXxp. HSCI Vertex Pharmaceuticals ISSCR Martin Pera

I’ve finally settled back home in Sydney, Australia with my family. I’d like to thank Doug and all my colleagues in the The Melton Lab for the wonderful years together. Hope to see you soon Down Under!

Check out our latest pre-print entitled “Whole Genome CRISPR Screening of Stem Cell Derived Islets Reveals Gene Targets for Hypo-Immunogenicity”

Happy to share a pre-print of some work from my time in the The Melton Lab. First and foremost, many thanks to all the co-authors involved!! Now, for a brief outline of the findings..

Cell maturation: Hallmarks, triggers, and manipulation The Melton Lab Harvard University Juan Alvarez UPenn CDB @IRM_Upenn Cell #ISSCR2022 hubs.li/Q01dFNRR0

Tomorrow 6/16 at #ISSCR2022, excited to present 'Immunogenicity of stem-cell derived islets as defined be a whole-genome CRISPR screen'. In person or virtual. 1:45pm PDT/4:45pm EDT, at 'Stem Cell Bioengineering - enhancing cell function'.

Couldn’t ask for a better closure for my postdoc era. Was so great to attend and present at #ISSCR2022! Met so many old and new friends/colleagues. Some of which you see only in meetings like these every few years. Hope to see you all next year in Boston #ISSCR2023 ISSCR

Take a look at the speaker line-up for #CSStemCells22, including keynotes Hans Clevers, The Melton Lab & Gordana Vunjak-Novakovic #stemcells #LosAngeles #California Cedars-Sinai Academic Medicine hubs.li/Q01d-_NX0

Using a CRISPR screen and single cell analyses we asked how do stem cell-derived islets (SC-islets) react to immunological pressure (allogeneic). Among the hits we identified CXCL10 depletion as a way to escape immune rejection of grafted #betacells. cell.com/stem-cell-repo…

G. Oliver Oliver Lab (🇺🇸Northwestern Feinberg School of Medicine), C. Blanpain Cedric Blanpain (🇧🇪Université libre de Bruxelles) & D. Melton The Melton Lab (🇺🇸HSCI) are the guest speakers in the #ISDB2021 session “𝗙𝗿𝗼𝗺 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁 𝘁𝗼 𝗱𝗶𝘀𝗲𝗮𝘀𝗲” Join us in 🇵🇹👉 ISDB2021.com/registration

Looking forward to keynote talks from Hans Clevers, The Melton Lab & Gordana Vunjak-Novakovic Cell Symposia #CSStemCells22 #stemcells #LosAngeles #California Cedars-Sinai Academic Medicine December 8–10, 2022 Register here hubs.li/Q01rNvCk0