The ENCODE imputation challenge is now live! Sign-up, form teams, and impute your way to cash awards sponsored by @LifeEpigenetics! synapse.org/encodeimpute

I have postdoctoral positions in machine learning and genomics/proteomics available in my lab. noble.gs.washington.edu/postdocs.html Come find me if you are at #ISMBECCB19

The MEME Suite of motif-based sequence analysis tools was the subject of my very first bioinformatics paper way back in 1996. The web server (meme-suite.org) has been in operation ever since. Now you can install it directly on your Mac: "sudo port install memesuite"

Our latest Journal of Proteome Research paper was featured on GenomeWeb, which is pretty cool 😎 genomeweb.com/mass-spec/uw-t…

I'm honored to have received an Am Soc for Mass Spec postdoctoral career development award. asms.org/about-asms-awa… Big thanks to all my mentors (Kris Laukens, Bart Goethals, William Stafford Noble, Pieter Dorrestein) and collaborators (CompOmics, @[email protected], many more) over the years.

My lab has an open position for a software developer to support our Percolator machine learning engine for mass spectrometry analysis. uwhires.admin.washington.edu/eng/candidates…

Thanks for funding Percolator, CZI.

Excited for another 5 years of studying genome 3D architecture! newsroom.uw.edu/news/nih-funde…

Not going to lie. Part of the reason I created an account was to promote this preprint of mine. We have created a new score, MS1Connect, that measures the similarity between pairs of mass spectrometry runs solely using MS1 scans and without any peptide identifications. 🧵 1/9

The state of the art in de novo peptide sequencing has just advanced: meet Casanovo, a transformer model that translates from the sequence of peaks in a spectrum to the sequence of amino acids in a peptide. biorxiv.org/content/10.110…

Our featured article: Navigating the pitfalls of applying machine learning in genomics go.nature.com/3D55JuZ #Review by Sean Whalen, Jacob Schreiber, William S. Noble & Katherine S. Pollard Gladstone Institutes Stanford University University of Washington UW Genome Sciences UC San Francisco Chan Zuckerberg Biohub Network

Our paper about building spectral libraries from DIA data is officially out Journal of Proteome Research! Thank you to everyone who worked on this and to our reviewers for their feedback, I'm very excited about the final product.

Obligatory post following a bioRxiv submission. In this work we show that 1) PSM-level FDR estimates in practice are invalid and 2) a simple variant of the peptide-level FDR estimate protocol can yield a significantly greater number of peptide detections

Check out Polarbear🐻‍❄️, a method to predict the missing scATAC-seq profiles just based on scRNA-seq, and vice versa. 🐻‍❄️ also derives matching in between scRNA-seq and scATAC-seq profiles, enabling integration of different types of single cell measurements. link.springer.com/chapter/10.100…

Casanova is the new state of the art in de novo peptide sequencing. biorxiv.org/content/10.110…

Interested in de novo peptide sequencing from #massspec #proteomics data? Check out our latest #preprint about Casanovo! 👉 doi.org/10.1101/2023.0… That's right folks - it's time for another #tweetorial 🧵 (1/9)

Congratulations to Lincoln Harris on being awarded an NRSA fellowship!

Want to learn more about the state of the art in de novo peptide sequencing at #ASMS2023? Come check out our: - Evening workshop #17 for a Casanovo tutorial on Monday - Talk at the AI session on Wednesday #TeamMassSpec

I am deleting my Twitter account. Please follow me on BlueSky (Will Noble.bsky.social).