Congratulations to three extraordinary scientists!!

I was pretty busy yesterday answering lovely emails, so am belatedly saying a few things now: What a huge honor, especially to receive this thing with the amazing Doris Tsao and Winrich. What I did was child’s pay compared to the sophisticated work they carried out subsequently.

Defeating imposter syndrome by actually being incompetent

NS&B end of 3rd cycle lunch, with our fabulous teams of students and TAs Olivier Dubanet and Peng Xu! Two weeks later, we have an avalanche of data. Many thanks to Marine Biological Laboratory (MBL), ZEISS Microscopy for an AxioZoom scope, Hamamatsu for an Orca Fire camera, and Charles Felts at RPI.

Fat cells are beautiful 😍 📸: @BartDeplancke

1/6 Exciting news! Our paper is now online in Cell! We've developed PRESYNAPTIC sensor and silencer for peptidergic transmission. The sensor detects LDCV release events, and the silencer specifically degrades neuropeptides inside the LDCV. authors.elsevier.com/a/1jTSjL7PXqREw

PSA: Cool kids apply for the NS&B course - you should, too

A new Nature study found a brain-wiring pattern linked to depression. 🧵1/12

A brain circuit that cements the memory of socially learnt food preferences go.nature.com/3XyCwoq

“It is my privilege to have been there at the very beginning.” —#LaskerLaureate Svetlana Mojsov on receiving the #LaskerAward for her work on GLP-1-based therapy for #obesity. #Lasker2024 Rockefeller University

Marie Curie was the first woman to win the Nobel Prize. This didn't happen because she herself fought for it -- although she did fight hard the whole way to even get to that point. 👩‍🔬 What happened was that the award was offered to her husband, Pierre. (1/n) 🧵

Excited to announce that our 2025 Advanced Research Training Course schedule is up and applications are open! 🎉🎉🎉 See you in Woods Hole! mbl.edu/courses

Yay. Finally it is out! If you are curious about how the brain controls the jaw in response to hunger you should read this: nature.com/articles/s4158…

Thrilled to share our paper online nature (on my birthday)! We've identified a new population of LepR neurons (BNC2) in the hypothalamus ARC that acutely suppresses appetite by directly inhibiting AGRP neurons, decoding the missing LepR GABAergic neurons. nature.com/articles/s4158…

I am thrilled to share the published version of our study on how neuropeptide signals regulate feeding in the hypothalamus! We imaged endogenous peptide signals in subcellular compartments during behavior. Below is an updated summary: rdcu.be/dZlI3

Apropos of never ending discussions about whether ANNs are "good" models of the nervous system, here is a slide I present to masters students showing a network that is found in motor control circuits *across phyla* (that's pretty ubiquitous!) I ask them to guess what it does...

C. elegans interprets dietary quality through context-dependent serotonergic modulation biorxiv.org/cgi/content/sh… #biorxiv_neursci

Gene editing technology began by people studying salt marshes. Ozempic began by folks studying the venom of Gila monsters. Support for basic science has empowered us to understand our world. Tethering it to applications health has transformed and saved countless lives.

ATLAS, a rationally designed transsynaptic tracer is out today! Plasmids will soon be available on Addgene addgene nature.com/articles/s4159… Many thanks to first authors Jackie Rivera and Haoyang Huang, and to collaborators, Bernardo Sabatini Scott Kanoski Weiguang Weng 🦄💨✨ Bruce Herring