1/n New preprint alert! 🚨🧬✨ The question we asked; is the genetic architecture of a complex trait different at the extreme ends of the distribution (i.e. tails) or similar to that in the main part of the trait distribution? #ASHG2024 #ASHG24 --> check out poster 4051T! 🧵👇🏾

Reminder that science is political whether you like it or not. Politics define how we are funded and what we are funded for. Politics define what we are able to study. Politics define who will be allowed in our labs and workplaces. Politics define with whom we can collaborate.

Divergent reference genomes compromise the reconstruction of demographic histories, selection scans, and population genetic summary ... biorxiv.org/cgi/content/sh… #biorxiv_evobio

1/7 🧬 New Preprint Alert: Our study highlights the risks of using divergent reference genomes in population genomics. The choice of reference genome can skew key inferences about demography, diversity, and selection. Read on for insights! biorxiv.org/content/10.110…

For folks still here, the first big project from my group is pre-printed. Super talented postdoc Maria Akopyan explored how reference bias can skew estimates of diversity, demography, divergence and recombination rate with help from Ellie Armstrong 🦁🐯🐻 and @GMenchev. Thread 👇🏽

Also super pumped that mPCRselect is out in MER. This work was co-led by @_ellie_cat and Julie Li with some new sims from Tessa Ferrari 🏳️‍🌈 and software updates from Michael Campana. mPCRselect can take a user's VCF and conduct marker selection for individual ID and pop ID

VERY excited to have this work out at Molecular Ecology Resources today - Next-Generation Snow Leopard Population Assessment Tool: Multiplex-PCR SNP Panel for Individual Identification From Faeces doi.org/10.1111/1755-0… Dmitri Petrov @_ellie_cat Shakeel Ahmad Muhammad Ali Nawaz

biorxiv.org/content/10.110…

BREAKING: A federal judge has blocked President Trump's executive order that sought to end government support for programs promoting diversity, equity and inclusion. apnews.com/article/dei-di…

Good news SLiM fans-- if you are developing in SLiM and like to use vscode, I've just released a beta version of a vscode extension that deals specifically with SLiM/Eidos: github.com/andrewkern/sli…

In #GENETICS, Roshni Patel, @spence_jeffrey_, Jonathan Pritchard, and colleagues explored the use of conditional frequency spectra to study selection on complex traits that circumvent some of the limitations of #GWAS. From our new Biobanks Series, read more: bit.ly/4gXsc1x

This seems massively overhyped. "Creating the dire wolves called for making just 20 edits in 14 genes in the common gray wolf." In other words, it's not a dire wolf - it's a gray wolf modified to be more like a dire wolf. That's a cool achievement but they have not 'brought the

Received an Honorable Mention for my NSF GRFP proposal! It was very competitive year due to funding (< half the usual number of awards) so I’m very happy for an HM. Thanks to my mentors Jazlyn Mooney, PhD Arun Durvasula & Xinjun Zhang for their support & LORs! Congrats to the awardees🎉

Supplementary figure 16

My paper about type I error rates in Qst/Fst comparisons is now published in Genetics Society of America. Check it out here: academic.oup.com/genetics/advan…

In a new #GENETICS research, Dandan Peng, Mulder, and Doc Edge evaluate the performance of several ancestral recombination graph (ARG) estimation methods used for determining the historical time course of a population-mean polygenic score. Read more: buff.ly/Xr9nFjB

Really happy this one is finally out! Tessa worked super hard to get it across the finish line. Please read if you are thinking about how to or if you should scale your sims.

Very glad this paper is finally out!

Herasight, named after the goddess who threw her disabled child off a mountain, seems focused on public outreach using embryo selection for IQ to win over far rightwing pseuds & techbros