Have you ever doubted the importance of muscle health in type 2 diabetic risk? Check out our latest human study published in Nature Metabolism to see if we’ve cracked the code using a state-of-the-art recall by genotype and deep metabolic phenotyping nature.com/articles/s4225…

Finally created a profile on #bluesky yesterday. Took me 5 min to set up and found the interface pleasently similar. I encourage my scientific peers and academic institutions to join to make this platform a viable alternative to the decreasing signal/noise on X.

Come join us over on 🦋. Loads of scientist and researchers are building communities there. I went from 30 followers to 500 in about a week. It will be great!

Moving to BlueSky this very minute🙌 I hope you will follow me there for muscle science 🧬

In an article at ScienceNews Professor Erik A. Richter from University of Copenhagen Research shares insigths into new research that highlights that small cells lining human blood vessels have a significant role in causing insulin resistance, a critical aspect of metabolic disorders such as

Not leaving #myotwitter but joined #myoblue - please reach out bsky.app/profile/muscle…

Really proud of Olivia Conway presenting her exciting work using subcellular proteomics to study insulin action in adipocytes. #MetabolismInAction2024

Our new FASEBJ paper. We looked into mTOR Ser1261 phosphorylation in human and mouse muscle, proposed by Diane Fingar's lab to be first an Akt and then AMPK site regulating mTORC1 and 2 activity. Clearly AMPK site but impact on mTORC unclear in our hands faseb.onlinelibrary.wiley.com/doi/10.1096/fj…

Breakthrough science!

Check out our latest paper challenging the long-standing belief that insulin elicits a transient H₂O₂ production. New insights into skeletal muscle redox signaling and insulin action 🤩

UW-Madison has lots of openings for PI’s that are doing research in the field of aging. Below is just one example. Please RT and help make UW a mecca for research on sarcopenia. jobs.wisc.edu/jobs/assistant…

A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise journals.physiology.org/doi/abs/10.115…

Our most comprehensive review ever! With twiterless Amira Klip and Philip Bilan. #nexs A Comprehensive View of Muscle Glucose Uptake: Regulation by Insulin, Contractile Activity and Exercise | Physiological Reviews | American Physiological Society journals.physiology.org/doi/abs/10.115…

🐭❄️ Temperature impacts molecular changes linked to cancer & cachexia in mouse models -something to consider when interpreting preclinical results and their translation to human cancers. Huge thanks to Andrea Irazoki & team onlinelibrary.wiley.com/doi/10.1002/jc…

New! Online now: NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging dlvr.it/TKT483

In our latest paper, we show that inducible sk. muscle AXIN1 /2 double KO have normal AMPK, mTOR and glucose uptake regulation, questioning previously proposed dependencies on this scaffold protein. Thanks to all co-authors for their contributions physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

Thrilled to share our new study from the Thomas E. Jensen lab showing, for the first time, that mitochondrial H₂O₂ is sufficient to trigger muscle wasting signatures and suppress protein synthesis. Huge thanks to Carlos Henríquez-Olguin and everyone involved! biorxiv.org/content/10.110…

🚀New preprint w/ Roberto Meneses-Valdés: We used chemogenetics to precisely control mitochondrial H2O2 in skeletal muscle in vivo. This exposes a dose-dependent sequence: translation suppression → proteolysis → denervation-like → degeneration Thomas E. Jensen biorxiv.org/content/10.110…