Today in Science Magazine, together with my former colleagues at NIBR, we report the discovery and characterization of first molecular glue degraders of the WIZ transcription factor (TF) for fetal hemoglobin derepression and therapeutic consideration in Sickle Cell Disease. 1/10

TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules

A heads up to all post-docs - the Genome Biology dept @EMBL is recruiting - independent group leader (PI) position. Outstanding colleagues, students, world-leading core facilities in a very supportive, collaborative and family environment, #jobs. Ad will be posted in next days

[ASAP] Racetrack FAIMS for High-Resolution and High-Sensitivity Characterization of Peptide Conformers dx.doi.org/10.1021/acs.an…

For those attending the final morning of #IMSC2024, I'm giving a talk covering decades of secret instrument development, and the coming-of-age of multi-reflection analyzers.

You have a strong background in bioinformatics🖥️, data science📈, machine learning, and multi omics? You want to do a PhD👩‍🎓facilitating non-clinical safety assessment? If so, come and join our ProteomicsDB team. mls.ls.tum.de/compms/job-off…

One day we will wonder why humans were doing all the pipetting

Teeradon Phlairaharn's work I believe.

It's a wonderful opportunity at #HUPO2024 to reconnect with my incredible mentors. Hamish Stewart Brian Searle 😙

It was a pleasure to have a wonderful lunch together during #HUPO2024 Brian Searle Mathias Wilhelm Hamish Stewart .

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Check out our approach on "non-destructive transcriptomics via vesicular export" (NTVE)! We have benchmarked NTVE exclusively in stably integrated cell lines, where transcript alterations by perturbations were truthfully reflected in the supernatant. ,biorxiv.org/content/10.110…

Excited to share 'non-destructive transcriptomics via vesicular export' (NTVE). We use HIV-1 virus-like particles, to export 'snapshots' of a cell’s transcriptome, which allows to follow gene expression changes over time by sampling from the supernatant. biorxiv.org/content/10.110…

We are excited to share our new Nature Methods paper describing the Chip-Tip workflow for single-cell proteomics identifying >5,000 proteins in single cells, enabling PTM analysis without enrichment and throughput of up to 120 single cell samples per day: rdcu.be/d6qJe

🚨 Our #singlecell article is out! We describe the Chip-Tip label-free SCP workflow quantifying >5000 proteins in single HeLa cells. With high scalability, increased depth and throughput we can now envision large-scale LFQ-SCP biomedical studies! nature.com/articles/s4159…

doi.org/10.1016/j.cell… ENVLPE, our system for VLP-based delivery of gene editors, is now published in Cell. We showed efficient delivery of base- and prime-editors in primary T cells & in vivo retinal models. Congrats co-first-authors Julian Geilenkeuser & Niklas Armbrust!

Improving proteomic dynamic range with Multiple Accumulation Precursor Mass Spectrometry (MAP-MS) biorxiv.org/content/10.110… #biorxiv_biochem

Give MAP-MS a try on your Orbitrap- no hardware or software changes needed! Curious how it works? Check out Brian Searle tweet for the details. #MassSpec #Orbitrap #asms2025 Huge thanks to coauthors and everyone who supported us during this work!

Delighted that Teeradon Phlairaharn's paper on MAP-MS is out! pubs.acs.org/doi/10.1021/ac… It changes how precursor ions accumulate in Orbitraps to achieve 2× dynamic range without consequences, improving DDA and DIA. It's a free instrument upgrade requiring no special software for Lumos on up!

It was a lovely chance to share a bit about this work and journey in the „Researcher Spotlight“ interview. ionopticks.com/2025/09/17/whe…