We are excited to share our latest preprint on a new solution to next-generation peptide/protein sequencing. Peptide sequencing via reverse translation of peptides into DNA biorxiv.org/content/10.110…

I am excited to share a part of my postdoctoral work that came out today in nature. We developed a single-cell nascent RNA sequencing method (scGRO-seq) that, among other applications, can help generate enhancer-gene maps. 🧵1/13 nature.com/articles/s4158…

CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release dlvr.it/T8Y1Vb

youtu.be/nWhqiEdda8Q?si…

⚡️ Children and mothers after being evacuated from the Okhmadyt hospital in Kyiv that was hit by a Russian missile. The name Okhmadyt means maternity and childhood care.

Targeting a hospital with children who have cancer is beyond comprehension... Another example that Russia is a terrorist state!

Happy to share our latest review, in which we discuss how small-scale 1D features of nucleosome positioning influence large-scale 3D genome folding patterns: sciencedirect.com/science/articl… Great team work with Abrar Aljahani and Clemens Mauksch!

TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules

Extremely happy to see our story out in Molecular Cell! doi.org/10.1016/j.molc… We show how Ki-67 & pre-rRNA phase separate, gluing mitotic #chromosomes together! 🧼🧬🧲 @EMBL EMBL Heidelberg Uni Heidelberg ISTAustria Cuylen Lab Andela Saric Ellenberg Lab

Our latest paper is out today Molecular Cell! Led by a Alberto Hernandez-Armendariz and with important contributions from Andela Saric & Ellenberg Lab! We show how chromosomes shift from being repulsive to becoming attractive during mitosis. Read all about it here: cell.com/molecular-cell…

EMBL Heidelberg researchers found how chromosomes switch from repelling each other to becoming sticky during cell division. They saw that protein Ki-67 turn chromosomes’ surface into a liquid-like glue that helps in the formation of daughter nuclei. 🔛 embl.org/news/science-t…

Wouldn’t it be great to test how individual transcription factors engage with their motif in the nucleus? We tried exactly that in a study lead by Ralph (Ralph Grand) and Marco (Marco Pregnolato) now out in Molecular Cell authors.elsevier.com/sd/article/S10…. 1/7

I am excited to join Caltech Chemistry & Chemical Engineering Caltech as an Assistant Professor this November! The Fianu Lab will be a welcoming space for anyone interested in gene activity and genome stability. bit.ly/47gH9I7 We are looking for team members at all levels—please reach out!

First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.110… (1)

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

What is the most common type of mutations, causing cancer and genetic diseases? C to T mutations in CpGs: Signature 1. What is the best understood mutational signature? Signature 1. Or is it? Results of over 8 years of our work is finally out! 🧵1/ nature.com/articles/s4158…

Very pleased to share our work on the polyadenlyation-independent termination of Pol II by the helicase Sen1. nature.com/articles/s4159… Extremely grateful to the generous freedom and support of Patrick Patrick Cramer for developing this work. A short 🧵 below.

Our new paper is out Nature Cell Biology🥳It shows how major epigenetic OFF mark, H3K27me3, is newly established at the beginning of life. This work was mainly carried out by a talented PhD student, Masahiro Matsuwaka👏 nature.com/articles/s4155… rdcu.be/dYJf Short summary↓↓