Fantastic Mount Sinai Division of Gastroenterology Grand Rounds talk by Aasma Shaukat MD MPH on CRC screening! Aside from colonoscopy, potential future options include multitarget stool RNA and DNA tests, cfDNA blood based tests, AI/machine learning. Organized screening & programmatic approaches will work best.

In this study led by Yael Bar & Dr. Neelima Vidula, they found that while the incidence of new actionable alterations (AA) decreased on serial cfDNA draws, new AA in previously unaltered genes continued to emerge in HR+/HER2- metastatic #breastcancer : nature.com/articles/s4152…

Exciting findings from Mass General Cancer Center using Guardant Health G360 to track actionable alterations in metastatic breast cancer in ctDNA. Implications for treatment selection, especially in HR+/HER2- MBC. #breastcancer #genomics #precisionmedicine
nature.com/articles/s4152…

The proportion of patients with an actionable alteration (AA) in serial cfDNA decreases with time - Elisa Agostinetto

npj Journals

oncodaily.com/52468.html

#oncodaily #oncology #cancer #npjJournalsBreast #cfDNA #metastaticbreastcancer #HRpositive #HER2negative #TNBC #HER2positive …

Also - make sure you sign up for the Pre- #EFI2024 Workshop on Monday 20 May:
✅ LABScreen.
✅ MagSort.
✅ ExPlex.
✅ Accept cfDNA.
✅ LIMS.
✅ Automation.
Shout & we can hook you up.

Is #SamplePrep important for #liquidbiopsy success?

More info bit.ly/3U9xcWR

#cfDNA #cfRNA #CTCs #SamplePrep Matters #oncologyresearch

It's been great working on this project as part of an amazing interdisciplinary team! We used machine learning classifiers and #cfDNA methylation profiling to predict, from a blood sample, the primary tumour type for CUP patients CRUK National Biomarker Centre Alicia Conway Natalie Cook 💙

cfDNAって何のために？

What is the importance of using dd-cfDNA technology as a surveillance transplant tool? Watch Dr. Yazir Qazi discuss his approach to cfDNA surveillance. ow.ly/lu3Q50QFlTT
#Natera #ProsperaKidney

Tune in to our 3-part video series describing analysis of cell-free DNA (cfDNA). Hear about the new custom library prep solution for cfDNA from Illumina and our customer’s case study on whole exome sequencing of cfDNA in metastatic prostate cancer. bit.ly/3w5Ih3g

JamesTheRight XxGodFatherxX The cool thing about $PDSB cancer vaccine is that while it was not originally testing for ctDNA/cfDNA reductions, PDS outside investigator partner MD Anderson is and results are incredible.

pdsbiotech.com/images/pdf/MDA…

Work by Alicia Conway and colleagues!

World CUP Awareness CUP Foundation CRUK National Biomarker Centre Natalie Cook 💙 NIHR Manchester Biomedical Research Centre

nature.com/articles/s4146…

Unfortunately the majority aqueous humour samples collected during intrevitreal chemotherapy (IViC), which is often performed quite late in the treatment process, did not contain 250pg of cfDNA and variant detection was not possible.

FinaleMe: Predicting DNA methylation by the fragmentation patterns of plasma cell-free DNA. #DNAmethylation #cfDNA Nature Communications
nature.com/articles/s4146…

Shows the potential for serial cfDNA testing in tracking actionable mutations for metastatic breast cancer patients. While promising, larger studies are needed to confirm impact on patient outcomes. #MBC #cancerresearch #precisionmedicine

Congratulations to Arpit Panda from the He lab who will be defending his thesis today titled 'Using molecular cfDNA markers to assess minimal residual disease in bladder cancer and exploring mechanisms of radiation-induced metastasis using single-cell RNAseq'! 🥳

#Liquid #biopsy is a non-invasive diagnostic technique used for the diagnosis of #breast cancer which involves the analysis of #various biomarkers, such as circulating tumor cells (CTCs), cell-free #DNA (cfDNA), and other.

To Get More: tinyurl.com/mpsvsvbv

#Healthcare

Vanadis NIPT sistemi, üç cihazdan oluşan bir platformudur:

Vanadis Extract®: Plazmadan cfDNA'nın otomatik olarak ekstraksyonu

Vanadis Core®: cfDNA’nın otomatik olarak işlenmesi

Vanadis View®: Floresan DNA moleküllerinin otomatik olarak görüntülenmesi ve sayılması+

However aqueous humour collected by anterior chamber tap after 1-2 cycles of chemotherapy provided enough cfDNA in all 11 cases and the detection of both causal variants in 10/11 patients.

Study population: n=485 consecutive patients with metastatic breast cancer (MBC) who underwent plasma-based cfDNA testing (G360) at MGH from 2016-2021. Patients with known MBC subtype and at least 1 cfDNA test result were included, divided into 3 cohorts based on HR/HER2 status.