SGLT2 inhibitors الكلاس السحري
• في مارس 2013 وافقت ال FDA على استخدام دواء canagliflozin كأول دواء من هذه العائلة لعلاج السكري من النوع الثاني
• بعدها في يناير 2014 تم الموافقة على dapagliflozin من نفس العائلة اتبعه empagliflozin في مارس من نفس العام

أدوية SGLT2 inhibitors
تنتهي ب gliflozin
Empagliflozin
Dapagliflozin
Canagliflozin
Bexaglifloxin
Ertugliflozin

تمنع إعادة امتصاص السكر و الصوديوم في الكلى عن طريق تثبيط ناقل الصوديوم و السكر المشترك:
Sodium/glucose cotransporter 2
مما يؤدي لخفض سكر الدم.
#صيدلة

Canagliflozin benefits in #NAFLD .
academic.oup.com/jcem/advance-a…

المجموعة الرابعة
مثبطات ناقل الصوديوم و الغلوكوز ٢
SGLT2 Inhibitors
Sodium Glucose co-Transporter 2 Inhibitors
تعتبر مجموعة حديثة التصنيع لضبط مستويات سكر الدم تعمل على طرح الغلوكوز بشكل أكبر في البول عن طريق الكلية .
Empagliflozin
Dapagliflozin
Canagliflozin
#أدوية_السكر

💊Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors

🔹 Medications in the SGLT2 inhibitor class include canagliflozin, dapagliflozin, and empagliflozin.

Bexaglifozin is now the fifth SGLT-2 inhibitor approved in the US, along with Invokana (canagliflozin), Farxiga (dapagliflozin), Jardiance (empagliflozin), and Steglatro (ertugliflozin).

Treatment with canagliflozin is associated with cardiorenal benefits in people with type 2 diabetes.
diabetesjournals.org/care/article/4…

Canagliflozin $243/month Mark Cuban Cost Plus Drug Company. Expensive, but a huge price cut. costplusdrugs.com/medications/in…

11) So what was the result of CREDENCE❓

⤵️ primary composite outcome (end-stage kidney disease, doubling creatinine, death from kidney/

⤵️ end-stage kidney disease

⚠️ No increase in amputation or fractures

👉 It worked! SGLT2i ⤵️ 'HARD' outcomes (well canagliflozin at least)

هل تعتقدون ان استخدامات هذه العائلة توقفت عند هذا الحد؟
- طبعًا لا!
• في ذات العام تم الموافقة على استخدام canagliflozin و dapagliflozin في علاج مرضى السكري الذين يعانون من مرض الكلى المزمن CKD.

Canagliflozin is most likely to reduce HF events in pts with diabetes who are at highest risk for HF hospitalization

Risk-based allocation of SGLT2i may help in low resource settings

Shahzeb Khan Javed Butler ambarish Harriette Van Spall, MD MPH Muthu Vaduganathan

jacc.org/doi/abs/10.101…

SGLT2 inhibitors in patients with type 2 #diabetes and #MASLD . #empagliflozin #dapagliflozin #canagliflozin American Diabetes Association
diabetesjournals.org/spectrum/artic…

🎉Cost Plus Drugs is excited to offer branded medications, manufactured by JanssenUS.

Invokana® (Canagliflozin)
Invokamet® (Canagliflozin-Metformin HCl)
Invokamet® XR (Canagliflozin-Metformin HCl)

Sign up and ask your provider to send your Rx to Mark Cuban Cost Plus Drug Co.

This week! ECP Seminar (ECP 8100/PHAR 6160): 'The Protective Effects of Canagliflozin against Carfilzomib-induced Endothelial Toxicity,' presented by Mohamed Dabour, ECP PhD student

10) So what about dedicated kidney outcome studies in DKD❓

🔸Data from CVOTs showed 2ry outcomes with preservation of kidney function

👉 1st DKD trial powered to detect 'HARD' outcomes was the CREDENCE Trial

🌟canagliflozin 100mg

🧑‍🤝‍🧑
🔸 #type2diabetes
🔹eGFR ≥30-90
🔸urine

“Yes, I accept the geroscience hypothesis.” 😌

Rapamycin & Canagliflozin

Two drugs consistently shown to increase lifespan across model organisms

😭 this was me for… ezetimibe, sulfamethoxazole/trimethoprim, umeclidinium, canagliflozin, fluorouracil, and rasagiline etc

#Canagliflozin promotes healthy brain aging #MAC2023 MidwestAgingConsortium Hashan Jayarathne Wayne State University Biological Sciences

Results Ora Biomedical, Inc. #millionmoleculechallenge

SGLT2 inhibitors (empagliflozin, dapagliflozin, and canagliflozin) failed despite canagliflozin showing life extension benefits in mice (NIA's ITP).