A recent study published in @scienceMagazine by Casanova Lab (award winner of I Edition), András N. Spaan and others, reveals that a rare autosomal dominant haploinsufficiency of #OTULIN impairs intrinsic cellular immunity to #staphylococcal alpha toxin. science.org/doi/10.1126/sc…
Now in Science Magazine: András N. Spaan, Casanova Lab & al describe rare autosomal-dominant #OTULIN haploinsufficiency. It impairs host defense to #staphylococcal α-toxin & is unique defect of non-hematopoietic cell-intrinsic immunity to bacterial infections! bit.ly/Sci_abm6380
ScienceMagazine: RT Seth Thomas Scanlon: Now in Science Magazine: András N. Spaan, Casanova Lab & al describe rare autosomal-dominant #OTULIN haploinsufficiency. It impairs host defense to #staphylococcal α-toxin & is unique defect of non-hematopoietic cell-intrinsi…
Now in Science Magazine: András N. Spaan, Casanova Lab & al describe rare autosomal-dominant #OTULIN haploinsufficiency. It impairs host defense to #staphylococcal α-toxin & is unique defect of non-hematopoietic cell-intrinsic immunity to bacterial infections! bit.ly/Sci_abm6380
Now in Science Magazine, András N. Spaan & colleagues show that human #OTULIN #haploinsufficiency impairs cell-intrinsic immunity to the #staphylococcal alpha-toxin edu.nl/hv4mk. 1/6
1/ Today in Science Magazine, we show that human #OTULIN #haploinsufficiency impairs non-leukocytic cell-intrinsic immunity to the #staphylococcal alpha-toxin. science.org/doi/10.1126/sc…
Our March issue is online today! Editorial from EMBO Mol. Medicine chief editor P. Sansonetti on #COVID19 vaccination & correspondence on One-Health surveillance, but also articles on #psoriasis (our cover), #cancer and #metastasis, #OTULIN mutations, & more! 👉 embopress.org/toc/17574684/2…
Compound heterozygous variants in #OTULIN are associated with fulminant atypical late-onset ORAS By C. Schuetz, P. Fischer-Posovszky, KM Debatin & colleagues Universität Ulm TU Dresden #OTULIN -Related #AutoinflammatorySyndrome -> Read #openaccess: doi.org/10.15252/emmm.…
📢Paper alert! This new study in Nature Communications explains the role of #otulin and #ripk1 mediated #keratinocyte #necroptosis in skin #inflammation. 🎉Congratulations to the Pasparakis lab from #sfb1403, CECAD Cologne and the Dikic lab ➡️nature.com/articles/s4146…
The July issue Trends in Immunology is out!! #Tick #host #immunity, #crohnsdisease, #NLRP3 & #cancer, #OTULIN & disease, #hypoxia & host #microbiota, #postnatal #oral immunity, #carbohydrates & #allergy & #immunotherapy & more!! cell.com/trends/immunol…
#OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting #FADD- and #RIPK1 Kinase-Mediated Hepatocyte #Apoptosis Verboom et al. in Cell Reports cell.com/cell-reports/f…
OTULIN prevents mTOR-driven liver disease | #Liver #OTULIN #ubiquitin #HCC #fibrosis #apoptosis #mTOR #rapamycin | David Komander & Rune Busk Damgaard DavidKomanderLab Rune Busk Damgaard MRC Laboratory of Molecular Biology Cambridge University Hospitals NHS WEHI (Walter and Eliza Hall Institute) UniMelb MDHS | Preprint bioRxiv Immunology bit.ly/2lWbqJP