Last week at PWS, resident Catherine presented on management of Raynaud's Phenomenon.
#OTILT Topical nitrates are considered second-line therapy for RP with intermittent episodes affecting various digits.

Each week we look forward to our Pharamacy Weekly Seminar where residents and students present a formal presentation or journal club!

#OTILT : Ketamine in Status Epilepticus is twice as effective if administered early, with an efficacy rate as high as 64%!

#TwitteRx #PharmRes

#OTILT Clostridium difficile is typically flora that can be found the GI tract. However, a cx positive for c. diff does not necessarily mean we need to treat! Colonization is when it is detected but the pt is asymptomatic. Infection requires a positive TOXIN +symptoms.

Last Friday at PWS, our resident Briana put together an intense game of jeopardy for our residents and students!

#OTILT : Loratadine is effective in preventing bone pain in patients receiving pegfilgrastim

Congrats to our resident, Jenny, for being the winner!🏆 #TwitteRx

For seizure management, time is of the essence and Benzos are first-line therapy! Use a large enough benzodiazepine dose to give the best odds of seizure termination.

#pharmacy #RxPearls #TwitteRx
#Pharmacist #pharmacy student #medstudent #nursingstudent #OTILT

Cryoprecipitate, platelets, and Jehovahs Witnesses, oh my! Getting smarter hanging with Dr. Evelyn Lockhart 🧠🩸 #otilt #PGY2 #hemesuperstar allison burnett Anticoagulation Forum UNM Pharmacy Residencies

#OTILT
Amyotrophic Lateral Sclerosis is a progressive neurological disorder that affects the neurons and nerve cells for voluntary muscle movement and breathing. Available agents, Riluzole, Edaravone, and Tofersen, can only improve quality of life and slow progression, not treat

E.Mcgee
PCOMGeorgia
#OTILT
#PHAR327EG

Fluoroquinolones are often associated with cardiotoxicity and QTc prolongation. Moxifloxacin may carry the highest risk of cardiac events, followed by lexofloxacin, with ciprofloxacin having lower rates of cardiotoxicity. #OTILT
pubmed.ncbi.nlm.nih.gov/30368737/

Brandon Dionne, Jeff Pearson, David Kubiak, Noa Slotky, PharmD, RPh. #OTILT

#OTILT is that C. parapsilosis has elevated MICs to echinocandins.
@ruchisane Brandon Dionne Jeff Pearson David Kubiak journals.asm.org/doi/10.1128/AA…

Corynebacterium striatum is commonly found on the skin and in mucous membranes, and can cause serious infections in immunocompromised individuals. Immunocompetent patients are also at risk due to the increasing rate of nosocomial C. striatum . #OTILT
ncbi.nlm.nih.gov/pmc/articles/P…

A serum potassium goal in a cardiac unit is 4 mEq/L. When repleting potassium each 10 mEq we give a patient will increase their serum potassium by 0.1 mEq. It is better to use oral potassium when possible because IV potassium is caustic and can be painful #OTILT

#OTILT
Daptomycin may induce eosinophilic pneumonia which typically presents as fever, dyspnea, pulmonary opacities and a bronchoalveolar lavage with > 25% eosinophils. The best treatment for the condition is to discontinue the daptomycin and consider the use of corticosteroids

#OTILT
The aminoglycoside class is known to have cross-resistance when organisms are resistant to gentamicin. For example, tobramycin is not active against gentamicin-resistant Enterobacterales, however, it has shown activity against gentamicin-resistant Pseudomonas aeruginosa

#OTILT fluconazole should be dose adjusted in renal dysfunction🫘 but are we underdosing? A 2020 study recommends new daily dosing for critically ill patients with invasive candidiasis⬆️: 600mg for adequate renal fxn and 400mg for poor renal function to achieve an AUC/MIC of 100

#OTILT VLA15 is the Lyme Dx vaccine currently in development. It's a multivalent subunit vax that targets B burgdorferi's outer surface protein A (OspA), which is expressed when present in a tick.
The vax works by blocking OspA➡️inhibiting bacterium's ability to leave the tick

#OTILT while dalba (a long-acting potent gram pos abx with activity against MRSA and strep) is only FDA-app for SSTI, it has shown promise in bacteremia and IE in PWID and those with other barriers to care. Bc of its long t1/2 (170-210h) it can be dosed q1-2wk.

#OTILT In 1998 the LYMErix 💉was approved that used recombinant outer-surface protein OspA. LYMErix showed a 76% decrease in lyme after 3 doses (@ month 0, 1, and 12). It was pulled off the market by the manufacturer after increased reports of arthritis and musculoskeletal sx.

Last ID #OTILT !🦠
Cefazolin and Rifampin combination can cause increased risk of clotting. When used together, the disassociation of the N-methylthiodiazole side chain can lead to decreased levels of vitamin K-dependent clotting factors and result in a prolonged INR