Georg Ehret, MD FESC FAHA INFLAVAS Francisco Rios A13: These are lipid mediators, right, and they show short half-life. We used IP injection every second day.
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Guto Montezano Francisco Rios INFLAVAS Hypertension We did not see effects in control mice at least in CV function and structure
Guto Montezano INFLAVAS Hypertension Francisco Rios RvD2 binds to GPR18 which is expressed in cardiovascular cells but mainly in immune cells. Most info on SPMs comes from studies in immune cells
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Francisco Rios INFLAVAS Hypertension A3: That is difficult to say. When there are inflammatory signals, resolution activates but if this is insufficient or inflammation is too high, then it can induce organ damage. 1/2
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Francisco Rios INFLAVAS Hypertension A5: We observed that AngII infusion did not increase leukotriene C4 synthase (Ltc4s) gene expression. Also, the mass spec approach did not show differences in leukotriene levels among groups.
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Q12- Hi, I am sorry for joining late. Congrats on your #hyphip Ana Briones. Could you comment on any relationship between aspirin and resolvins? Wonder if low dose aspirin could be protective in HTN. Thanks Hypertension
Carmen De Miguel, PhD, MS, FAHA UAB Nephrology INFLAVAS AHA Science Francisco Rios Thank you Carmen, muchas gracias!
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Carmen De Miguel, PhD, MS, FAHA Francisco Rios INFLAVAS Hypertension We measured electrophysiological properties and cytokines expression. Both data indicated m2 polarization by RvD2
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Dr Anastasia Mihailidou FAHA FCSANZ FESC Francisco Rios INFLAVAS Hypertension Guto Montezano A6. We haven´t looked at sex differences in expression but some evidence suggest that females may produce more SPMs than males
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Carmen De Miguel, PhD, MS, FAHA INFLAVAS Francisco Rios A15: We are currently analysing the kidneys of these mice. Preliminary data suggest that seems to be some positive effects on fibrosis as well.
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Pablo Nakagawa Hypertension A12. Yes, aspirin induces production of lipoxins, and it also produces a novel family of SPMs named aspirin-triggered SPMs.
I am not aware of studies using aspirin for HTN
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Pablo Nakagawa Ana Briones Hypertension LOL - Pablo Nakagawa we always repeat a questions in our #HYPHIP chats! This is a tradition now.
Francisco Rios INFLAVAS Hypertension Specialized pro-resolving lipid mediators (SPM) have been suggested to prevent cardiovascular damage in several pathological conditions, like atherosclerosis or aortic aneurysms, but little is known about their effect in hypertension. 1/2
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#HYPHIP Q13: Can you please tell us a bit more how the RvD2 treatment works ? I suspect that it is lipophilic, you used it iv. What's the half-life ?
Many thanks !
Ana Briones INFLAVAS Francisco Rios
Francisco Rios INFLAVAS Hypertension A11: Yes, several were detected but no differences among groups were observed
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Ana Briones Guto Montezano INFLAVAS Hypertension That's very true. There are very little information about the importance of these receptors in vascular cells. INFLAVAS Ana Briones #HYPHIP Hypertension
Francisco Rios INFLAVAS Hypertension A2: SPM are generally produced from immune cells and platelets, as well as during leukocyte-endothelial cells interactions. They come from omega 3 and omega 6 PUFAs. Specifically, RvD2 comes from DHA.
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Francisco Rios INFLAVAS Hypertension A9: That is a very interesting question. We do not have experimental data but it may be!
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Francisco Rios INFLAVAS Hypertension 2/2
In this work we demonstrate that the SPM RvD2 prevents and regresses some cardiovascular alterations induced by hypertension.
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INFLAVAS Ana Briones Hypertension Francisco Rios Sorry for my typos! Can't contain my excitement with this paper! INFLAVAS Ana Briones #HYPHIP 😆