🔶Investigadores del Cima y de la Clínica Universidad de Navarra confirman que el aumento de la molécula #FGF19 protege de la toxicidad causada por las sales biliares. Estas sales son necesarias para la regeneración del #hígado, pero deben controlarse para evitar la #hepatotoxicidad.

Merci CNRS Biologie de mettre en avant nos travaux #FGF19 #Aldafermin

🚨 Happy to share our #LiverCancer research! Our latest study reveals a surprising feature of #FGF19 analog #Aldafermin. A thread... 🧵 (1/10)

🚨Our work on #FGF19 oncogenic cooperation in #HCC is out EMBO Mol. Medicine ! 😊🍾 Big team work, led by José Ursic Bedoya and Guillaume DESANDRE #proudPI 👏👍 Congratulations to all, thank to collaborators (INRAE TIM) @IGMM_Montpellier, CHU de Montpellier embopress.org/doi/full/10.10… 1/5

#FGF19 and its analog #Aldafermin cooperate with MYC to induce aggressive hepatocarcinogenesis By José Ursic Bedoya, Guillaume DESANDRE, Damien GREGOIRE & colleagues CNRS 🌍 👉doi.org/10.1038/s44321…

New review from Wenzhou Medical University! Targeting the FGF19–FGFR4 pathway for cholestatic, metabolic, and cancerous diseases. 🔗doi.org/10.1111/joim.1… #bileacid #FGF19 #livertwitter

#ESMO23 3> #Gastrointestinal Cancer, #HCC 3-7> (1012P) First-in-human study of ABSK-011, a novel, highly selective fibroblast growth factor receptor (FGFR) 4 inhibitor for treating advanced hepatocellular carcinoma (HCC) with FGF19 overexpression. #FGF19-#FGFR4 pathway

🚨 Preprint alert !🚨 Happy to share our work: " FGF19 and its analog Aldafermin cooperate with MYC to induce aggressive hepatocarcinogenesis" Congratulations to José Ursic Bedoya , Guillaume DESANDRE and all coauthors 👏👍😀 @IGMM #FGF19 #Aldafermin #HCC biorxiv.org/content/10.110…

#PapersBiologiaUB | 💓🔬 La proteïna #FGF19 influeix directament en el desenvolupament de la hipertròfia cardíaca. 🏥 Aquesta connexió obrirà noves vies per al tractament de malalties cardíaques. 👏🏻 Enhorabona a tot l'equip! x.com/bqbiomedmolub/…

👉New Mini-Review in #ajpgi! Fibroblast growth factor 19 secretion and function in perinatal development by Caitlin Vonderohe et al. 👉ow.ly/1oWY50NzoQw #FGF19 #Perinatal #BileAcid #GITwitter

Researchers pave the way for solutions to problems affecting #preterm #infants. #FGF19 #cortisol Douglas Burrin Dr. C Vonderohe Agricultural Research Service blogs.bcm.edu/2023/03/23/fro… via BCMHouston

Interested in potential solutions to problems affecting #preterm #infants? Drs. C Vanderohe, Douglas Burrin et have published new findings and an invited #review on the topic. #Endocrinology #cortisol #FGF19 Oxford Academic Agricultural Research Service BCMHouston medicalxpress.com/news/2023-03-p… Medical Xpress

New findings on the regulation of #FGF19, a key molecular player at #birth, may be valuable to improve growth, metabolic and hepatic outcomes in #preterm babies. Douglas Burrin Dr. C. Vonderohe et al #Endocrinology Oxford Academic Agricultural Research Service blogs.bcm.edu/2023/03/23/fro… BCMHouston

🎇Newly accepted review in #ajpgi👉Fibroblast Growth Factor 19 Secretion and Function in Perinatal Development(Douglas G. Burrin et al.) 🖱ow.ly/ZB7550MuWqs #FGF19 #PerinatalDevelopment #BileAcid #Perinatal

‘Aim of this study was to evaluate the safety & efficacy of #aldafermin, an engineered analogue of the gut hormone fibroblast growth factor 19 (#FGF19).’ ‘Aldafermin was generally well tolerated but did not produce a significant dose response on fibrosis improvement... (2/3)

#ArticlesInPress "Fecal Microbiome and Bile Acid Metabolome in Adult Short Bowel Syndrome" by Harold J. Boutte Jr, et al ow.ly/Fb7V50H10cC #ajpgi #IntestinalAdaptation #ShortGutSyndrome #FGF19

Exciting work from Deb Rubin and her team @WUSTLPeds @wustlmed WashU Gastroenterology on the Fecal Microbiome and Bile Acid Metabolome in Adult Short Bowel Syndrome in AJP-Gastrointestinal and Liver Physiology! #fgf19 #shortgut journals.physiology.org/doi/abs/10.115…

This conversation focuses on the roles fibroblast growth factors (FGFs) play in fat metabolism, appetite and other issues related to Fatty Liver disease. #betaklotho #Phase2a #BALANCEDtrial #BALANCEDCohortC #FGF19 #adiponectin #adipocytes #insulinresistance