🚨Early-onset colorectal cancer (EOCRC, 20-49 y) incidence is increasing worldwide: Norway data
ESMO Open

➡️1993 and 2022
❗️Incidence of EOCRC increased by 66% (average annual percentage change, AAPC 1.3)
❗️Mainly left-sided colon and rectal cancers
✔️Age group 50-74 years:…

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Early onset colorectal cancer (EOCRC)
2 recent studies Annals of Oncology and JCO Oncology Practice

✅1️⃣Genome-wide association study and Mendelian randomization analyses

➡️6,176 EOCRC cases and 65,829 controls
➡️two novel risk loci for EOCRC at 1p34.1 and 4p15.33
➡️a deleterious…

second day #ASCO2023 thoughts:
🚨unmet need alert🚨
- beautiful waterfall for adagrasib in kras g12c solid tumors
- promising theories on early onset colorectal cancer & environmental influences of the microbiome
- potential targets for MSS TMB-high eoCRC (⬆️POLE mut -> ICI?)

Germline disparities in racial/ethnic groups in early-onset CRC ( #eoCRC ) show varied prevalence (9.5% to 14.0%) of germline genetic variants. MLH1, CHEK2, monoallelic MUTYH with the highest prevalence-> optimize genetic testing via ancestry sp. research
ascopubs.org/doi/10.1200/JC…

Pleased to announce that I’ll be presenting our abstract comparing surgical outcomes of Stage IV Early Onset vs Average Onset CRC at Digestive Disease Week! See you in D.C. 🚀 #EOCRC #AOCRC

What a RUSH! I still can’t believe I presented my research during the #ACG2023 presidential plenary session about the impact of the food environment on #EOCRC mortality! I couldn’t have done this without the BRILLIANT mentorship of Priya Vijayvargiya! So grateful to ACG!

Keynote lecture by Kimmie Ng, MD, MPH on EOCRC.
- ⬆️ incidence 🐘 in the room!
-Delays in diagnosis common
-Most are sporadic.
-Complex interplay of diet and lifestyle factors.
-Imp to look for targetable 🧬
- ⬆️ treatment ❎ translate into better OS, we need newer strategies!! #GI24

Wonderful few days at #RCGPAC in Glasgow. Great opportunity to promote EOCRC and our research into the referral challenges for these patients. #nevertooyoung Bowel Cancer UK

Tune in Sept 13 EARLY GASTRIC & COLORECTAL NEOPLASIA. Join Michelle Kim Carol Burke Carol Macaron David Liska Michael Cruise Amit Bhatt MD Kyungran Justina Cho (Justina Cho) Cleveland Clinic MD at CME MOC event. GIM, EOCRC, colorectal adenomatous polyposis, cases. Register bit.ly/LIVECCSep23

Our general GI consult team stopped by the WashU Gastroenterology inflatable colon today to kick off CRC awareness month. #getscreened #CRC #EOCRC Fight Colorectal Cancer

Thrilled to be participating in the ⁦Fight Colorectal Cancer⁩ early onset colorectal cancer think tank. Working together to move the science forward to turn the rising tide of EOCRC around. ⁦UChicagoCancerCenter⁩

Are you are a nurse caring for people with hereditary GI cancer, Lynch syndrome, polyposis syndromes or EOCRC? You might be interested in joining us as we continue to grow our #EHTG European Nursing Network👇
DM for the link

Un Estudio liderado por el IBSAL concluye que la medición temprana de TL y polimorfismos del gen POT1 podría ser clave para identificar a individuos en mayor riesgo de cáncer colorrectal.
#EOCRC #telómeros #POT1 #prevenciónCC
mdpi.com/1422-0067/24/4…

Keynote lecture World Congress on Gastrointestinal Cancerby Dr. Prof. Irit Ben-Aharon providing an excellent overview of early onset #CRC highlighting key findings and future directions. Excited to continue our research on eoCRC using multi-omics approaches  Alok Khorana, MD Suneel Kamath MD Smitha Krishnamurthi World Congress on Gastrointestinal Cancer #WCGI2023

The lay summary of our study on early onset colorectal (EOCRC) cancer is now available. Key findings:
- there is a lack of recognition for EOCRC patients.
- Areas of unmet need include information needs, mental health, sexual health and fertility counselling.
Paper coming soon.

SAVE THE DATE! En Julio vamos a estar en Congreso HOSPITAL CHIRIQUÍ /Panamá hablando de Cel Madre x Fistulas/EOCRC/Crohn.
Nos vemos ahi?
Juan C Patrón Uriburu @biti1706 Cihangir Akyol, MD Dr Luis Felipe Cabrera Vargas MD FACS MACC MACCVA Ruben Aguilar Zapag JUAN CARLOS REYES Isaias Padilla Mota Dra. Itzel Vela Lucia Oliveira,MD,PhD SURGERY Journal Julio Mayol

#WorldCancerDay #DiaMundialContraElCancer
📈Cada vez vemos más cánceres de colon en pacientes jóvenes
¿Algo mejor para leer en un día como hoy que este consenso de expertos internacionales?
#EOCRC
🔓 #OpenAccess
cghjournal.org/action/showPdf…

Summary on EOCRC epi trends by Rebecca Siegel ⁦Fight Colorectal Cancer⁩ Think Tank. Looking forward to forthcoming publication with new data. Key to remember important disparities in incidence, mortality & screening.

Similar factors increase the RISK of early-onset #ColorectalCancer (EOCRC) & later-onset colorectal #cancer (LOCRC), such as a #sedentary lifestyle, #obesity , and #MetabolicSyndrome , but there are also important differences. #ColorectalCancer Awareness science.org/doi/10.1126/sc…