We have a new website! Come see what is new and exciting at the uofl_STC! Melissa Smith. uoflsequencing.com

Stellar work by Eric Engelbrecht (Oscar L Rodriguez ; Melissa Smith) -- Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry biorxiv.org/content/10.110…

Immcantation.org user or interested in B cell repertoire analysis? Register now for “2024 Immcantation Users Group Meeting”. FREE virtual meeting 1/25/24 10-2PM (ET). All talks from user-submitted abstracts (due 12/1/23). Info at: kleinstein.bitbucket.io/IM #AIRRseq #meeting

Looking to the future of antibody genetics: resolving the roles of immunoglobulin diversity in gene regulation, function, and immunity | Genes & Immunity nature.com/articles/s4143…

Excited to announce that we are expanding our uofl_STC team with the hire of a new Director of Operations. Have genomics expertise and want to run a vibrant core facility full of wonderful people and fun custom assays? Apply today! DM me with questions! rb.gy/vhb7e5

New Research: AIRR-C IG Reference Sets: curated sets of immunoglobulin heavy and light chain germline genes: Introduction Analysis of an individual’s immunoglobulin (IG) gene repertoire requires the use of high-quality germline gene… frontiersin.org/articles/10.33… #immunology

🗓️ AGRF Seminar: Translational Research in Action this Thursday 22nd February at The Westmead Institute for Medical Research. 💻Register here to secure your free ticket: agrf.org.au/events/transla… Together with our partners PacBio Westmead Research #AGRF #Genomics #Clinical #Translational #Seminar #Research

Hearing from Dr Melissa Smith @SmithLab_UoL, a new appreciation of the expansive nature of allelic variation in immune antigen receptors… things are getting complicated… PacBio Monash Biomedicine Discovery Institute #seminar #genomics #bcellsarecool #tcellsarecool

Check out "Digger", a new tool for annotating immune receptor genes from genomic assemblies. Gur Yaari Swati saha and william lees doi.org/10.1093/bioinf…

Delighted to be attending the amazing AIRR Community Meeting VII - Learnings and Perspectives. Register now and join in on the fun! whova.com/portal/registr… #airrc7 - via #Whova event app

Come see our #AAI2024 poster today to find out how we are leveraging long reads in antibody repertoires to address questions in autoimmunity. Board605! Melissa Smith Corey Watson

#AIRRC7 day 1. All you ever wanted to know about IG an TR germlines

Bill Schief presents groundbreaking data highlighting a path towards a vaccine inducing broadly crossreactive antibodies against HIV-1. #AIRRC7 #antibody

Easton Ford (University of Louisville) presents recent technology developments for the near full-length resolution of antibody heavy chains (FLAIRR-seq) applied to Acetylcholine Receptor Myasthenia Gravis (AChR MG) #AIRRC7 Full agenda: tinyurl.com/airrcmeeting7

We are still looking for the perfect person to lead the uofl_STC into the future of genomics. We are a research genomics core, so get ready for lion, tiger, and bear (genomes), oh my! Please amplify! DM me for further information and/or apply here: tiny.cc/oejdyz

Eric Engelbrecht showing us that we have much to discover in the human IGK locus! Gene conversions, novel inversions, SVs, SNVs, genes and alleles...oh my! rdcu.be/dJ8mL

More work from Eric Engelbrecht and Oscar L Rodriguez on the value of long-reads for investigating the regulation of V(D)J recombination doi.org/10.4049/jimmun…

Haplotype-resolved 6 great ape genomes using PacBio WGS + Iso-Seq for genome annotation. 215 gapless T2T chromosomes. Comparative analysis show higher divergence in centromere, telomere, aceocentric, SDs, 5- to 15-fold difference. ~40-45% of gorilla & orangutan genomes are

So proud of Easton E. Ford - you deserve all the accolades!

Pre-print alert🚨: "A Broad Survey and Functional Analysis of Immunoglobulin Loci Variation in Rhesus Macaques" biorxiv.org/content/10.110… A truly enjoyable and collaborative effort—this is what science should be all about! Steve Bosinger Corey Watson