Since anti-IL11 and rapamycin (which can also boost lifespan) both converge on MTOR, it'd be interesting to put anti-IL11 head-to-head against rapamycin - maybe that's the next paper Widjaja et al in Nature (nature.com/articles/s4158…)

The addition of blinatumomab to consolidation chemotherapy in adults with B-cell precursor acute lymphoblastic leukemia who had minimal residual disease–negative status after treatment improved overall and relapse-free survival. Full trial results: nej.md/4deohvj

Happy to share our paper describing the benefit in addition of Blinatumomab in Newly diagnosed MRD negative B cell ALL. Congratulations to all who were part of this cooperative effort! nejm.org/doi/full/10.10…

Please join our Virtual Open House on August 20th, 2024, to learn more about our residency program! Webex link: hhc.webex.com/hhc/j.php?MTID… Meeting number: 2318 783 4603 Password: jacobi@1 Andrew Gutwein MD #MedTwitter #Match2025 #residency

A new manuscript from #shastrilab just dropped! "A STAT3 Degrader Demonstrates Preclinical Efficacy in Venetoclax Resistant AML". Congratulations to first author Samarpana Chakraborty & a huge thanks to amazing collabs & Kymera Therapeutics EinsteinSCI Montefiore Health System biorxiv.org/content/10.110…

It is a great honor and privilege to present at European Society of Medical Oncology. #ESMO2024 I’m grateful for the academic support from my residency Jacobi Internal Medicine Chiefs and Chul Kim, who have continuously guided me in my growth as a future academic oncologist, even from 🇰🇷!

🔥 Our clinical trial of metronomic low-dose decitabine-ven in frontline MDS/ AML shows low tox, high efficacy & high response rate in TP53 mutant pts!! pubmed.ncbi.nlm.nih.gov/39316768/ Amit Verma Aditi Shastri, MD Ioannis Mantzaris Marina Konopleva Yogen Saunthararajah Montefiore Health System Albert Einstein College of Medicine - Official #leusm

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

As part of our wellness activities, our residents had the opportunity to unwind and relax with Cooper, one of Jacobi's therapy dogs! 🐶

As the interview season begins, we are excited to introduce our future chief residents for the 2025-2026 academic year! 🎊

The National Institutes of Health has awarded Aditi Shastri, M.D., and Sofiya Milman, M.D., M.S., a five-year, $5.18 million grant to research aging-related CH in two Ashkenazi Jewish cohorts that include individuals aged 95 and older. Learn more at bit.ly/4egoleg.

1/ JUST IN: an 8 year #kidneycancer journey now published in nature: “A personalized neoantigen vaccine generates anti-tumor immunity in high-risk renal cell carcinoma”. A trial of #RCC vaccine, led together with first author David Braun Yale Cancer Center and #PatrickOtt #DerinKeskin

It was a great pleasure to co-author this review on recent updates in STAT biology & therapeutics in Myeloid malignancies with Sudhamsh Desai Zoe King & David Frank ! Emory University EinsteinSCI Albert Einstein College of Medicine - Official Montefiore Health System

🔥 Excited for our Phase 1 study Ven + 7+3 for Newly Diagnosed AML demonstrating 85% CR (86% MRD-neg) Blood Journal @ MontefioreNYC Albert Einstein College of Medicine - Official Montefiore Health System Eric J. Feldman Mendel Goldfinger Marina Konopleva Amit Verma Aditi Shastri, MD Kira Gritsman #leusm doi.org/10.1182/blood.…

The addition of blinatumomab after induction chemotherapy in children with standard-risk disease of average or higher risk of relapse significantly improved disease-free survival. Full AALL1731 phase 3 trial results: nej.md/49CVkc1

I’m thrilled to share that our abstract has been accepted for poster presentation at EHA25 under Myelodysplastic syndromes / Stem cell transplant - clinical category. Indebted to my mentors and collaborators on this multi-institutional project for their invaluable support.

Yes, I know it’s late but worth the wait. Our incoming chief residents kicked off their journey in New Orleans with the dream team PD & 2 APDs. We are ready(ish) for next academic yr. #aaim #gme Jacobi Internal Medicine Chiefs

Congratulations to the graduating class of 2025! We are wishing each of them continued success as they take the next step in their journey!

In our study just published in Blood Cancer Journal Outdoor Air Pollution(OAP) , particularly PM2.5 was associated with a trend towards worse survival in #multiplemyeloma patients treated in a historically redlined area - Bronx, NY. EinsteinSCI Montefiore Health System Albert Einstein College of Medicine - Official