Stephen Dorn has a detailed thread to show all our results. He also implemented these new ensemble features in our PUMAS software. Stephen is applying for PhD programs this year. Look out for his application. We want him in Wisconsin too! Thread🧵:x.com/stphn_drn/stat…

I’ll be attending NeurIPS Conference 2024 to present our work on a task-agnostic approach to leveraging AI/ML predictions for rigorous statistical inference in scientific research. Excited to connect and discuss AI4Science (biology, genetics, and medicine).

Excited to share the paper: Huntington's disease is a DNA process for almost all of a cell's life. Inherited HD alleles are innocuous, just unstable – CAG repeats slowy expand throughout life. We call it a "ticking DNA clock". cell.com/cell/fulltext/…

Beyond excited to share this new paper with all of you . It's the most fun we've ever had. We figured out how to study a latent index driving partner choice without measuring it directly🥂 Qinwen Zheng Preprint📰: biorxiv.org/content/10.110… Sumstats⬇️: qlu-lab.org/data.html

A very interesting read on the genetic architecture of partner choice "index" — or according to economics literature our "attractiveness in the marriage market"🧬 1/5

I and my colleague, Sahar Gelfman, at RGC had the privilege to write a News and Views article for @nature about a recent work on Huntington's disease by Steve McCarroll and team. In this incredible work, through an innovative single cell RNA sequencing methodology, Handsaker et

14% of 55-69 men with polygenic risk scores (PRS) in the top 10% had prostate cancer classified as intermediate or higher risk, a higher percentage than would have been identified using PSA or MRI screening. This seems like a strong argument for integrating polygenic risk scores

In Nature Genetics we report that base editing of trinucleotide repeats (TNRs) reduces somatic repeat expansions in Huntington’s disease (HD) and Friedreich’s ataxia (FRDA)—in patient-derived cells and in vivo—a collaboration with the Mouro Pinto lab. drive.google.com/file/d/1on7kdy… 1/14

Jiacheng Miao's PIGEON paper on GxE methodology is now published Nature Human Behaviour with a new title. In our view, this paper can reshape the study design for future complex trait GxE work. Paper📰doi.org/10.1038/s41562… Software🧑‍💻github.com/qlu-lab/GSUB

🚀 Introducing Paper2Agent - a system that turns static research papers into interactive AI agents you can chat with and use the tools/data in the paper. Just ask, “Run this paper’s method on my data.” The paper agent will handle the task for you. 1/n

I've finally digested the data that Uniqure presented on AMT-130, their gene therapy for Huntington's disease, which just announced a positive trial readout with 75% slowing of disease progression. Here is a blog post with my take on the announcement: cureffi.org/2025/10/08/amt…