COQ8B gene deficiency linked to retinal disorders in pediatric kidney transplant recipients; CoQ10 may offer protective benefits. by Feng Y, Feng Y (...) Shang W et 8 al. in Hum Mol Genet academic.oup.com/hmg/article-ab… #MedX #MedResearch

Targeting CDH1 mutations in hereditary diffuse gastric and lobular breast cancer could revolutionize treatment and improve patient outcomes significantly. by Corso G, Magnoni F (...) Albini A et 5 al. in Hum Mol Genet academic.oup.com/hmg/article-ab… #MedX #MedResearch

Old and new local ancestry inference methods deliver similar results, but discordance in select regions signals potential genomic complexities. by Chen X, Wang H (...) Sofer T et 9 al. in Hum Mol Genet academic.oup.com/hmg/article-ab… #MedX #MedResearch

Naturalistic conversation enhances language localization accuracy and neuropsychological outcomes, outperforming traditional task-based methods in epilepsy surgery patients. by Ervin B, Frink C (...) Arya R et 9 al. in Ann Neurol onlinelibrary.wiley.com/doi/10.1002/an… #MedX #MedResearch

PD1-axis emerges as key player in maintaining immune tolerance; alterations linked to chronic inflammatory demyelinating polyneuropathy severity in patients. by Sgodzai M, Klöster K (...) Pitarokoili K et 22 al. in Brain academic.oup.com/brain/advance-… #MedX #MedResearch

Bone Health Alert: Trabecular Bone Score Drops 1.43% Over 12.5 Years in Healthy Young Men, Linked to BMI and Fat Levels. by Sertons Y, Banica T (...) Verroken C et 4 al. in J Clin Endocrinol Metab academic.oup.com/jcem/advance-a… #MedX #MedResearch

Spironolactone fails to lower cardiovascular deaths or heart failure hospitalizations in patients on maintenance dialysis, trial halted for futility. by Walsh M, Collister D (...) Devereaux PJ et 27 al. in Lancet thelancet.com/journals/lance… #MedX #MedResearch

Spironolactone fails to protect haemodialysis patients from major cardiovascular events; off-label use remains unsupported by evidence. by Rossignol P, Zannad F (...) Frimat L et 28 al. in Lancet thelancet.com/journals/lance… #MedX #MedResearch

Efruxifermin delivers significant fibrosis improvement in MASH patients after 96 weeks, outpacing placebo and prompting phase 3 trial exploration. by Noureddin M, Frias JP (...) Yale K et 15 al. in Lancet thelancet.com/journals/lance… #MedX #MedResearch

Intraoperative autologous blood transfusions do not elevate early cancer recurrence risks during major oncologic resections; re-evaluate their use. by Powell C, Day C (...) Thiels C et 7 al. in Ann Surg Oncol link.springer.com/article/10.124… #MedX #MedResearch

Cardiac MRI Phenotyping Reveals High-Risk Groups in Non-Dilated LV Cardiomyopathy, Enhancing Prognostic Stratification and Management. by Jiang M, Zhou W (...) Lu M et 12 al. in Heart heart.bmj.com/content/early/… #MedX #MedResearch

Interpersonal Violence in Gymnastics Leads to Complex Outcomes: Former Elite Athletes Link Trauma to 54 Negative and 7 Positive Effects by Barker-Ruchti N in Br J Sports Med bjsm.bmj.com/content/early/… #MedX #MedResearch

Linking threat perception and control to aggression, adolescents with certain psychotic-like experiences show measurable behavioral impacts, challenging misconceptions. by Redman SL, Pitts SC (...) Schiffman J et 8 al. in Schizophr Bull academic.oup.com/schizophreniab… #MedX #MedResearch

Semaglutide promotes weight loss in veterans with schizophrenia and multimorbidity, but results are less pronounced than in non-schizophrenic peers. by Browne J, Wu WC (...) Rudolph JL et 14 al. in Schizophr Bull academic.oup.com/schizophreniab… #MedX #MedResearch

Parent advocacy intervention boosts service access for recently graduated autistic youth, but shows limited impact overall, demanding further exploration. by Taylor JL, DaWalt LS (...) Slaughter JC et 2 al. in J Child Psychol Psychiatry acamh.onlinelibrary.wiley.com/doi/10.1111/jc… #MedX #MedResearch

ISG15 deficiency in hepatic stellate cells accelerates liver fibrosis by enhancing TGFβ2 signaling, highlighting a potential therapeutic target. by Yuan Y, Li J (...) Zhao J et 8 al. in Gut gut.bmj.com/content/early/… #MedX #MedResearch

Fibromyalgia Index scores correlate with altered brain connectivity in nociplastic pain, underscoring its neurobiological relevance and specificity. by Kelleher EM, Lange F (...) Irani A et 6 al. in Brain academic.oup.com/brain/advance-… #MedX #MedResearch

Advanced oxidation protein products activate TRPA1, driving nociception and anxiety in relapsing-remitting multiple sclerosis—new therapeutic targets emerge. by Rodrigues P, Frare JM (...) Trevisan G et 23 al. in Brain academic.oup.com/brain/advance-… #MedX #MedResearch

NLRP3 inflammasome emerges as a central player in inflammation, paving the way for targeted therapies in various diseases. by Weber ANR, McManus RM (...) Latz E et 3 al. in Nat Immunol nature.com/articles/s4159… #MedX #MedResearch

Rhesus macaques reveal structural diversity of broadly neutralizing antibodies targeting HIV-1 V2 apex, crucial for vaccine development. by Roark RS, Habib R (...) Shapiro L et 39 al. in J Exp Med rupress.org/jem/article/22… #MedX #MedResearch