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Excellent 🧵

A methylation #clock predicts risk of #COPD exacerbation. Better than most blood biomarkers. rdcu.be/cGpIB

Congrats to Maria and Leo on their new paper which hits the ground today in Nature! nature.com/articles/s4158…. Describes a unique airway cell in humans lungs that can act as a progenitor for AT2 cells (RASCs). Keep up the great science MorriseyLab, Maria C. Basil, @leoviral3!

Led by Mahyar Aghapour (Mahyar Aghapour), researchers at Guericke University discuss the immunological mechanisms involved in physical barrier disruption induced by airborne pollutants and outline their implications in asthma and #COPD. ERS publications | 📑 bit.ly/3ITp19t

The respiratory microbiome encompasses bacterial, fungal and viral communities. In health, it is a dynamic structure and dysbiotic in disease. Dysbiosis can be related to disease severity and may be utilised to predict patients at clinical risk. bit.ly/3pNSgnA

When the Australian Government gets published in Nature before I do…. Yet another international embarrassment #fixNHMRC nature.com/articles/d4158…

🚨Hot off the press! Just in time for #ATS2022 Fluticasone-based ICS/LABA therapy is associated with changes in the small airway #microbiome🦠 that are related to gene expression changes in #COPD🫁 Full text 🔗mdpi.com/1626102 Graphical Abstract 👇

IgG subclass deficiency is associated with increased mortality in #COPD. An important (unrecognized) phenotype in patients with repeated exacerbations. Correctable with replacement therapy. rdcu.be/cOIML

It is always gratifying to see a student complete their research degree - congratulations Blake Handley on the award of your MPhil on breathing protocols in multiple breath nitrogen washout testing #MBNW Physiology @Woolcock

#eosinophils may be important in #COPD but measurements in the lung (blood is not a surrogate). Even with small samples, BAL #eosinophils predict risk of #AECOPD but blood does not. mdpi.com/1678314 #mdpibiomedicines via Biomedicines MDPI

Immensely honoured to receive this prestigious Research Trainee award from Michael Smith Health Research BC ! Under the expert supervision of Don Sin at HLI at St Paul's @UBCmedicine Congratulations to the other trainees and their mentors!

Latest Online! 🥳 "Model analysis of multiple breath nitrogen washout data: robustness to variations in breathing pattern" by Jason H.T.Bates and co-workers Paul D Robinson 🫁 Cindy Thamrin Read it on #JCMC #Physiology #pulmonary #MedTwitter Link: link.springer.com/article/10.100…

Knowing what to call your "Lung macrophage" can be so hard- alveolar v airway v lung but this great review on the biology of lung macrophages in health and disease Immunity is helping us to start defining better well done Claudia Jakubzick lab 🫁👏 cell.com/immunity/fullt…

❗️Attn Twittersphere. Our Aussie friend/colleague Stanley is missing in Seattle, discharged from Valley Med Center with confusion 4 days ago. In Seattle as a tourist. Has a personal affinity for hospitals, cruise ships so may have made his way to somewhere similar. Please help❗️

UPDATE: Stanley has been found and is now recovering. Thank you for your concern, I know there is a big bunch of people in Sydney who are very relieved!

Brilliant 👏

Very pleased to have joined the editorial board at #BMCPulmMed 📖 Looking forward to seeing the latest in cutting edge respiratory science coming across my desk!

Fantastic collaborative work (Sydney+San Diego) on gas exchange abnormalities post-COVID-19. Could persistent shunt and/or dead space drive pulmonary symptoms in #LongCovid ? The Westmead Institute for Medical Research