Are drug effects on mRNA & protein levels similar? Below are example dose-response curves of drug-induced changes in protein (blue) and mRNA (pink) abundance. 1/n

MedTox Fellows. 33 YOF c/o syncope but strongly denies use of any meds, including OTCs. ECG NSR with QTc 620 ms. Stat UDS below. Name the agents, or their parent compounds, that can lengthen QT.

FUN FACT Earthworms don’t have red cells, but their blood is red. Why? Because they have Hb (Fe-bound heme groups in Hb gives blood its red color), which floats freely in plasma as a 3.6 MDa mega-complex (erythrocruorin), and carries oxygen efficiently underground.

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before inhalers, there was Asthmador: an over-the-counter anti-asthma cigarette containing jimsonweed and nightshade

MedTox Fellows: Don't be discouraged when you don't recognize a toxidrome in a comatose patient. This is a typical urine drug screen at our center. It is the exception to ever find a single substance. Meth, ketamine, fentanyl and PCP.

Hospital pro tip: Put a Chux pad on your seat and no one will steal it.

History of silicosis litigation. An interesting read. schachtmanlaw.com/2019/01/31/his…

acpjournals.org/doi/10.7326/ai…

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Tox fellows, in over 45 years of caring for TCA ODs, I can't recall ever seeing mydriasis. Mydriasis should be good evidence against a TCA as primary agent. Why do most TCAs not have mydriasis?

This. At the level of the pupil, TCAs produce about as much alpha blockade and muscarinic antagonism. Pupils usually unremarkable.

MedTox Fellows: The toxicity of which one of the following metals is decreased by hepatic methylation in human beings? A. cadmium B. mercury C. bismuth D. selenium E. lead

MedTox Fellows: A faculty member found this upon opening the garage upon returning from work this morning. Genus species? What venom component exhibits kallikrein activity?

Now is as good a time as any to remind you that you probably owe your life to an objectively evil man. Except… if that's true, was he actually evil at all? This week, we tell a twisted story from long ago…

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