Today at #ANEUPLOIDY22: replication defects and their link to chromosome instability (and vice versa), centrosome amplification, how chromosomal instability relates to efficacy of cancer treatments, how to reliably measure chromosome instability.

What better way to get to know us than through the eyes of our residents? Join us on 9/28 or 10/11 for a virtual meet & greet! Get all your questions answered about #HROP #RadOnc Sign up here: surveymonkey.com/r/JQB5BN6

#ANEUPLOIDY22 It was truly a fantastic meeting and a wonderful tribute to Angelika. Thank you Stefano Santaguida, Jason Sheltzer, Eduardo Torres and Beth Weaver for making this possible. Hoping to see everyone again in 2 years.

#Radonc physician-scientists, join us for the annual #CROPS 🌽 happy hour!! Tues 10/25 6-8 pm, River’s Edge Cafe in the Hilton Palacio del Rio. Come by for any part. Pls RSVP if you think you can join us. Looking forward to seeing everyone in person! #ASTRO22 ASTRO ARRO

My apologies the word artistic I meant self-absorbed, and I apologize again

We want your research at #ANESCR to help organizers Godek Lab, @LabSpektor, and more unpack the Consequences of Aneuploidy. Submit your abstract by July 21 and save your space: hubs.ly/Q02FjvPq0

Abstract deadline coming up! Hurry and register to the FASEB "Consequences of Aneuploidy" meeting in Florida (Sep 15-19). This meeting gathers top scientists studying chromosomes, cancer genomes, mitosis and meiosis, and more. More details: events.faseb.org/event/conseque…

(1/5) I am delighted to share our study published today nature nature.com/articles/s4158… collaboration with @Chowdhury Lab, led by @XiaoZheng3and Aniruddha Sarkar PhD. Huge congratulations to all the authors and collaborators.

Cyclin Dependent Kinases (CDKs) are critical for regulating different phases of the cell cycle and CDK1 was considered to be the only CDK essential mitosis.

We found that these errors occur because spindle microtubules that separate sister chromatids during mitosis become abnormally stable in the absence of CDK5, preventing cells from correcting chromosome attachment errors.

Using two orthogonal chemical genetic approaches, we show that CDK5, an atypical CDK essential in non-dividing neuronal cells, plays an important role in mitosis in preventing mitotic errors. Abrogation of CDK5 prior to mitosis led to chromosome mis-segregation and nuclear atypia

With the help of our collaborator Amanda Paulovich, we used phosphoproteomic analysis to identify putative CDK5 substrates that may account for this phenotype.

Surprisingly, we discovered that CDK5 forms a functional complex with Cyclin B1, the mitotic cyclin that partners with CDK1 to complete all stages of mitosis.

Loss of CDK5-Cyclin B1 interaction abolished CDK5 activity in vitro (thanks to our collaborator Kavita Shah) and phenocopied CDK5 abrogation in mitosis. CDK5–cyclin B1 is thus a canonical CDK–cyclin complex that plays an essential role in maintaining genome integrity.

The study alters the existing paradigm that CDK1-Cyclin B1 is the only CDK-cyclin complex essential for all stages of mitosis and raises the possibility that other atypical CDKs may also have a role in regulating the cell-division cycle.

Because CDK5 is overexpressed in many cancers and is associated with a poor prognosis, our study raises the possibility that these cancers may be more dependent on CDK5 for their cell division and suggests that CDK5 may be an important therapeutic target.

Excited to welcome aneuploidy scientific community in sunny Melbourne, FL. Can't wait to see everyone. #ANESRC

Terrific session dedicated to the memory of Angelika Amon, with a tribute by Jason Sheltzer and outstanding talks by Jason Sheltzer, Zuzana Storchova, Stefano Santaguida and others. #ANESRC

Terrific session dedicated to the memory of Angelika Amon, with a tribute by Jason Sheltzer and outstanding talks by Jason Sheltzer, Zuzana Storchova, Stefano Santaguida and others. #ANESRC

#Radonc physician-scientists, you’re invited to the ELEVENTH annual #CROPS 🌽 happy hour!! Tuesday 10/1 6:30-8:30 pm at bartaco, 1025 5th St NW. Come by for any part. Pls RSVP if you think you can join us. Looking forward to seeing everyone!! #ASTRO24 ASTRO ARRO