🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Applying to the MIT BE PhD program? Join the BE Application Assistance Program (BEAAP) for informational webinar this Thurs 10/21 11am EDT. Hear from current students, get your questions answered. Open to all, so share widely! Register ow.ly/4e0n50GtVHE MIT School of Engineering

Ever wondered where Cas9 came from? Audrey Lapinaite and I wrote a 'First Cut' for The CRISPR Journal describing the epic work by Han Altae-Tran and colleagues on the origins of Cas9. Our summary: liebertpub.com/doi/10.1089/cr… The epic paper: science.org/doi/10.1126/sc… Phage be like👇

Calls for authors, interviewers, and editors for Volume III of MIT Science Policy Review! Applications are due Oct 29 (5PM EST)! Application form: docs.google.com/forms/d/e/1FAI…

The February issue is live nature.com/nbt/volumes/40… Our cover features a rendering of the predicted structure of an RNA editor based on the compact Cas13bt enzyme presented by Kannan et al. go.nature.com/3Dyjq6W

Online Now: Structure and engineering of the minimal type VI CRISPR-Cas13bt3 dlvr.it/SXDP2Z

Happy to announce our paper about the compact CRISPR-Cas13bt3 structures was published in Mol Cell! Congrats, Ryoya! Thanks for a fantastic collaboration with Feng Zhang . cell.com/molecular-cell…

Volume III of SPR is out now! Congratulations to all authors, editors and the leadership team on an exciting and informative set of articles

Out now in nature: 🧬 Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA. By Seiichi Hirano, Kalli Kappel, Feng Zhang & colleagues. Kalli Kappel Feng Zhang nature.com/articles/s4158…

We’re excited to report today in @nature the cryo-EM structure of the OMEGA family member IsrB in complex with ωRNA and target DNA. nature.com/articles/s4158…

Are you applying to bio-engineering PhD programs this cycle? Gain insight into submitting a strong application by joining a virtual info session led by MIT BE faculty and grad students. Fri 10/21 10am EDT. All are welcome. Register here: mit.zoom.us/meeting/regist…

Delivery of therapeutic molecules is a major bottleneck for treating a wide range of diseases. Today we describe a new modality for delivering proteins based on an engineered contractile injection system @nature nature.com/articles/s4158…

Building on our previous work characterizing the RNA-guided OMEGA systems IscB, IsrB and TnpB in prokaryotes, we report today the characterization of Fanzor, a eukaryotic OMEGA system. Congrats to Makoto, Peiyu Xu and the whole team on this comprehensive and elegant work!

We’re excited to share a new study enumerating diverse and rare CRISPR systems found in nature out now in Science Magazine. Thread coming soon!

‘Treasure trove’ of new CRISPR systems holds promise for genome editing go.nature.com/418u4Ol

Thank you Debojyoti Chakraborty and all the organizers for hosting such a fun meeting! I enjoyed talking with lots of motivated students, sharing some new work and getting a chance to visit Goa!

The clustering algorithm FLSHclust identifies previously unknown CRISPR-linked systems using a mining approach with great potential for advancing biotechnology development in both research and the clinic. #NBThighlight science.org/doi/10.1126/sc…

By analyzing bacterial data, researchers in Feng Zhang lab have discovered thousands of rare new CRISPR systems with a range of functions. mcgovern.mit.edu/2023/11/23/sea…

Using big-data approaches to rapidly search massive amounts of genomic data, a new search algorithm has revealed thousands of rare new CRISPR systems. broad.io/CRISPR-Zhang-1…

Check out Han Altae-Tran’s thread below for more info on our paper investigating rare CRISPR systems using big data approaches! Huge thank you to our team, collaborators and mentors Anthony, Kepler Mears, Esra, Lukas Moeller, Selin Kocalar, Rachel Oshiro, Kira, Rhiannon, Eugene and Feng Zhang

Our latest research, published in PNASNews, identifies nearly 1 million OMEGA-TnpB & CRISPR-Cas12 genome editors. Key insights? RNA-guided activity is linked to more processes than we thought: transcription, transposition, motility and more! doi.org/10.1073/pnas.2… #CRISPR (1/3)