Excited to share our preprint Jörg Vogel 𝗡𝗼𝗻-𝗴𝗲𝗻𝗲𝘁𝗶𝗰 𝗺𝗲𝘀𝘀𝗲𝗻𝗴𝗲𝗿 𝗥𝗡𝗔 𝘀𝗶𝗹𝗲𝗻𝗰𝗶𝗻𝗴 𝗿𝗲𝘃𝗲𝗮𝗹𝘀 𝗲𝘀𝘀𝗲𝗻𝘁𝗶𝗮𝗹 𝗴𝗲𝗻𝗲𝘀 𝗶𝗻 𝗽𝗵𝗮𝗴𝗲-𝗵𝗼𝘀𝘁 𝗶𝗻𝘁𝗲𝗿𝗽𝗹𝗮𝘆 doi.org/10.1101/2024.0… Universität Würzburg #UniWürzburg Helmholtz Institute Würzburg (HIRI) New Concepts in Prokaryotic Virus-Host Interaction #biotech #microbio #phage

Today in Cell we report evidence for a covalent linkage between small RNAs and N-glycans via acp3U Work by Yixuan (Axe) Xie Peiyuan Chai +collab w/Ben Garcia | HSCRB Excited to accelerate more work related to glycoRNAs in many new contexts. doi.org/10.1016/j.cell…

Excited to introduce AntiDefenseFinder - a free, open source tool that detects anti-defense systems in any genomic sequence. Available here to toggle on/off: defensefinder.mdmlab.fr. Read below for our insights into the >47K detectable systems📈 tiny.cc/8xrizz

New paper alert by LOlijslager ! academic.oup.com/nargab/article… "Distribution of specific prokaryotic immune systems correlates with host optimal growth temperature" A 🧵

Happy to share my first postdoc paper, out today in Nature! nature.com/articles/s4158… This started with a simple question: Can we learn more about viral proteins by looking at their predicted structures? /1

We wondered if eukaryotic DNA virus LigTs could be acting similarity to Phage Acb1 and degrading cGAMP. Using cell-based assays and biochemistry, we found that avian poxviruses encode LigTs that do indeed degrade cGAMP! Below are some TLCs with purified enzymes 8/

» The role of TIR domain-containing proteins in bacterial defense against phages | Nature Communications nature.com/articles/s4146…

Foldmason, our fast and accurate protein structure-base multiple sequence alignment method, has a logo thanks to HBKgenomics. Also, we updated the preprint, including a multi-domain protein benchmark. 📄biorxiv.org/content/10.110… 💾foldmason.steineggerlab.com 🌐search.foldseek.com/foldmason

Out in Cell Host & Microbe: Conservation of antiviral systems across domains of life reveals immune genes in humans. Using phylogenomics, we traced antiphage systems in eukaryotes, predicted human homologs and validated their immune function in human cells! cell.com/cell-host-micr…

Digging deeper, we could demonstrate, that two proteins of the key piRNA pathway involved in protecting the animal germline, MOV10L1 and PLD6, originated in Mokosh antiphage system

Through a combination of knock in, knock down experiments in cell lines and human derived macrophages, we could demonstrate that GIMAP5 and 6 are antiviral against Herpes Virus ! We could swap domains of bacterial Eleos in place of domain of GIMAPs, protein is still active!🦠👩‍🔬

My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/

Tricking phages with reverse transcription Ilya Osterman summarized the beautiful discoveries from the labs of Sternberg Lab and Feng Zhang, who showed how bacteria defend against phages by expressing a protein that is not really encoded in their DNA science.org/doi/10.1126/sc…

These kind of discoveries remind us all why we fell in love with biology and decided to make it our profession

WOW 👉Animal and bacterial viruses share conserved mechanisms of immune evasion: 👇👇👇 Cell cell.com/cell/fulltext/…

A new paper from Sam Hobbs in the Kranzusch lab (kranzuschlab.med.harvard.edu) demonstrates that animal and bacterial viruses use conserved strategies to defeat host antiviral immunity Cell cell.com/cell/fulltext/…

A postdoctoral position is available in our lab, available immediately. Ideal candidate will have experience with membrane proteins and an interest in bacterial immunity. RTs appreciated! jobs.ac.uk/job/DJO275/res…

The final version of our paper on anti-CRISPRs "in disguise" as Cas proteins is out today in Nature! Congrats to Mark, Edith and the whole team! nature.com/articles/s4158…

Continuous multiplexed phage genome editing using recombitrons go.nature.com/3yUNYTi

We’re presenting AlphaProteo: an AI system for designing novel proteins that bind more successfully to target molecules. 🧬 It could help scientists better understand how biological systems function, save time in research, advance drug design and more. 🧵 dpmd.ai/3XuMqbX