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Very excited to share our collaborative paper on the Cryo-EM of DNA-PK AstraZeneca NatureStructMolBiol BiocEM Cambridge Cambridge Biochemistry #DNArepair #NHEJ nature.com/articles/s4159…

Some new work from the Caldecott and Takeda labs! Finally, we have found what the majestic XRCC1 does during DNA base excision repair....an endogenous PARP1 anti-trapper 😊 sciencedirect.com/science/articl…

What happens to RNA transcription when PARP1 goes off the rails at BER intermediates? Exciting story form our lab Keith Caldecott nature.com/articles/s4155…

Four years later and my PhD is done 🎉 Thanks to Keith Caldecott for all his help and support and also to my examiners Penny Jeggo and Grant Stewart for their great discussion!

Very excited to share the results of my PhD at Keith Caldecott lab @GDSC_Sussex published today in NatureStructMolBiol showing that unligated intermediates of Okazaki fragment processing are potent lesions for PARP trapping! 1/2 nature.com/articles/s4159…

Graduation 🥂 Thanks Keith Caldecott for all your help and support!!

A new preprint from a fantastic collaboration with Keith Caldecott and Arnab Ray Chaudhuri driven by awesome postdocs Alice Meroni, Sophie Wells and Carmen Fonseca!!! (1/3) biorxiv.org/content/10.110…

Please see our new replication fibre preprint at biorxiv.org/cgi/content/sh… #bioRxiv . A lovely collaboration with Vindigni lab and Arnab Ray Chaudhuri by Alice Meroni, Sophie Wells and Carmen Fonseca.

New collaborative paper on replication fork collapse at SSBs in human cells, from Almu, Sophie and colleagues in the Caldecott/Hoch/Jackson labs. An essential read if you use BrdU/CldU/IdU for your replication experiments! protect-eu.mimecast.com/s/8GZICN05NT73…

Very excited to share our latest work from the ⁦Keith Caldecott⁩ lab with special thanks to our collaborators ⁦⁦Almudena Serrano-Benítez⁩ ⁦⁦Steve Jackson Lab⁩ and the Hoch lab! embopress.org/doi/full/10.15…

Very excited to share our work with Sophie Wells from Keith Caldecott lab, Hoch lab and our lab Steve Jackson Lab embopress.org/doi/full/10.15…

Our review on DNA damage and Transcription stress is out! Check it online at Molecular Cell, thanks to the nice work with Amit Gautam and Keith Caldecott cell.com/molecular-cell…

.Alice Meroni, Sophie Wells, Fonseca et al. show that DNA combing resolves sister chromatids, allowing the detection of strand-specific alterations, whereas DNA spreading typically does not. hubs.ly/Q02jQq4l0 Vindigni lab Keith Caldecott Arnab Ray Chaudhuri #DNABiology

Out now on JCB a wonderful group driven effort from Keith Caldecott Arnab Ray Chaudhuri and Vindigni lab led by Alice Meroni Sophie Wells and Carmen Fonseca!!! rupress.org/jcb/article/22…

Very excited to share our latest work on KU-binding motifs and replication stress!