Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking go.nature.com/3eILDvj

Nice method for doublet detection in single-cell experiments that builds on top of scVI.

MIT-Harvard suit against ICE: "ICE’s action proceeded without any indication of having considered the health of students, faculty, university staff, or communities"

Very cool paper on pooled knock-ins with single-cell RNA readout. Also very clearly written! sciencedirect.com/science/articl…

TODAY! Watch documentary Coded Bias screening at Provincetown Film Society. For tickets & more information, visit: provincetownfilm.org/festival/films… #CodedBias #Ptownfilm #Provincetownfilmfest #PIFF2020

Really cool: Simultaneous assessment of TF-binding and expression in single-cells. I really like the potential to use self-reporting transposons to record TF binding history through a lineage!

We’re excited to share our new paper in Nature Communications (tinyurl.com/yxojlzcz), describing our platform that enables multiplexed transcriptional profiling of chemical and genetic perturbations in large pools of co-treated cancer cell lines, with single-cell resolution.

Great review of tumor (neo-)antigens: sciencedirect.com/science/articl…

Very happy and proud to present: The GTEx papers. This set of 15 papers published today describes the final phase of this 10-year effort, providing the genomics community an atlas of genetic regulatory variants and a deep dive into the biology behind it. sciencemag.org/collections/ge…

Interested in the genetic basis of rare disease? Postdoc opening with Matt Hurles to link genetic + EHR data in large patient cohorts to identify novel causes of disease. jobs.sanger.ac.uk/vacancy/postdo… Partnership with Genomics England + HDR UK

It's like those COVID-tracking maps. Except seeing the numbers go up makes you feel good: electproject.github.io/Early-Vote-202…

Looking forward to the ML in Epigenomics meetup of the Bay Area Chromatin and Epigenomics community on Tue Nov 17th. Featuring Anshul Kundaje (anshulkundaje@bluesky)! meetup.com/Bay-Area-Chrom…

Great read! "Visible neural network" by the Trey Ideker group helps identify mechanisms of action of drugs and suggest synergistic drug combinations: cell.com/cancer-cell/fu… #drugdiscovery

I've binge-listened to "Invisible women" over the last couple weekends. I was aware of a lot of the biases, but some of the research was new to me. The accumulated evidence will make you angry - at least I think it should amazon.com/Invisible-Wome…

Our paper out in Nature Genetics uses CRISPR essentiality screen data to map gene function! Another beautiful collab w/ Mike Bassik, led by the outstanding Michael Wainberg, Roarke Kamber, akshay Balsubramani with invaluable contribs from coauthors. 1/

How vaccination successfully took on the B.1.1.7 variant cell.com/cell-reports-m… Cell Press

Check out a new method for single cell ATAC-seq analysis developed by Han Yuan and I based on the Basset model for predicting accessibility from DNA using deep conv nets biorxiv.org/content/10.110…

The Computational Biology and ML group at ArsenalBio is hiring! If you're excited about using your engineering and data analysis skills to meaningfully advance cell therapies against cancer, then come join us! jobs.arsenalbio.com/jobs/discovery…

Join us for a virtual event on the #epigenetics of #autism and neurodevelopment with Yihui Zhu and Kari Neier: meetup.com/bay-area-chrom…

The CompBio & ML group at ArsenalBio is hiring! jobs.arsenalbio.com/jobs/discovery…