I am super happy to share the first work of the lab on #gastruloids. All started with Marietta Hartl that was extremely brave to start a new project on early development. bit.ly/3ocuTqj With @SimonSuppinger they showed mechanisms of gastruloid development

Very proud to see our work on the pan-cancer comparison of the genomic landscapes of primary and metastatic tumor published in this weeks issue of Nature: nature.com/articles/s4158…. Francisco Martínez-Jiménez Arne Van Hoeck Hartwig Medical @UMCU_CMM Oncode Institute Vall d’Hebron Institute of Oncology (VHIO)

Are you looking to keep up to date with the rapidly progressing area of cancer genomics? 🤔 Then join us for #EMBLCanGen! ➡️ s.embl.org/can23-01 Submit your abstract by 23 Aug to be a part of this interdisciplinary community of cancer researchers 🥼 #cancerresearch

We welcome Sjors Middelkamp as our newest postdoc. He got off to a great start this week, being immediately awarded the NWO talent grant ‘Veni’ to continue his research on single-cell genome sequencing that he developed in the @BoxtelLab. @UMCU_CMM NWO Funding Oncode Institute

Walking on my way to EMBL cancer genome conference #EMBLCanGen Excited to present our newest work on early-stage colon cancer later today

Is #cancer drug resistance heritable or plastic? Genetic or non-genetic? How do we tell those apart? We just begun measuring the temporal dynamics of evolving cancers using controllable patient-derived #organoids. We need more experiments+theory! biorxiv.org/content/10.110…

Our lastest study "Targeted Perturbation of Signaling-Driven Condensates" is now live on Molecular Cell. We've used small peptides to specificaly disrupt β-catenin condensates, resulting in decreased transcription and inhibition of cancer cell proliferation. 🔬💡 📖 Read more:

Extremely honoured to receive the ERC Consolidator this year #ERCCoG. Looking forward to the next 5 years of exciting science to unravel the intricacies how tumors become malignant. #CancerPrevention @UMCU_CMM Oncode Institute

We are now live! Register for the 2nd OrganoidNL meeting AMOLF on April 12 🗓️. Exciting talks with opening Hans Clevers, keynote Margherita Turco, and talks from @JeroenPasterk Colinda Scheele, Rob Coppes and Quiwei Pan. amolf.nl/organoidnl-sym…

The 2nd edition of OrganoidNL was a great success! We are already looking forward to next year... stay tuned!

Check our our latest publication on mouse and human gastruloids in Cell Stem Cell, spearheaded by Suz with help from Maria Teresa Alejo Vinogradova and many others in our lab and in collaboration with labs of Boudewijn Burgering, Harm Jan Vos, Maarten Altelaar and Ina Sonnen

How does DNA damage cause apoptosis when p53 is mutated? Critical to understand treatment of many tumors. Excited that ‘DNA damage induces p53-independent apoptosis through ribosome stalling’ by Nicolaas Boon and collaborators is out: doi.org/10.1126/scienc…

Very much enjoyed that we could contribute to the latest discovery of the Brummelkamp team

Looking forward to present tomorrow morning at #FEBS2024. I’ll discuss our work on real-time single-cell signaling activities in #organoids, drug response and our latest push to advance the technologies involved @UMCU_CMM Oncode Institute

How do mismatch repair-deficient (MMRd) cancers trade off the evolutionary costs and benefits of elevated mutation rates? Delighted to share our paper on adaptive mutability in MMRd colorectal cancer (CRC) Nature Genetics nature.com/articles/s4158… Tweetorial 🧵below

Very much love this story to demonstrate that adaptability during tumor evolution can also be achieved at the DNA level by reversible DNA mutations 🔥 Marnix Jansen @UMCU_CMM Oncode Institute

1. Delighted to present work from my time in Andrea Sottoriva's lab, now in Nature Cancer! A big effort also led by Javier Fernández-Mateos and Nick Trahearn. We combined genomics + digital pathology to measure evolution in a prostate cancer (PCa) clinical trial. nature.com/articles/s4301…

New publication alert🚨🚨🚨Mechanisms that clear mutations drive field cancerization in mammary tissue is out nature nature.com/articles/s4158… Congratulations all for this great team work! 🎉

Big milestone for our group Epithelium Microenvironment Interaction Lab @ DKFZ DKFZ: We are thrilled to be among the recipients of an ERC Starting Grant from European Research Council (ERC) #ERCStG! In the #METABAC project, we will explore how gut #bacteria contribute to #colorectal #cancer #metastasis formation. (1/12)

1) Excited to share a ms entitled: Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D #organoid sheets. It describes an alternative to #Matrigel biorxiv.org/cgi/content/sh… A thread: