1/⚠️Important need to knowℹ️ for using BCMA-directed agents in #MultipleMyeloma Noopur Raje and myself have u covered 👇#MedTweetorial🧵gets u what u need 🏆🆓#CME 👉🏼 bit.ly/RRMM-TW5-CME Supported by edu grants from JanssenUS & @Pfizer 📍What’s your specialty?

...This could be improved by: 1) improved PK/PD leading to improved exposure (AUC 2) Improved supportive care (30% of Mel200 have severe fatigue >30 days), driven by high Il-6 and low WBC (role for Siltuximab)

In a couple of years we will talk about risk factor studies -- putting in a bunch of covariates in a multivariable regression model and declare the significant factors as important "risk factors" for health -- as one of the biggest mistakes in health research

Hot off the press the new ASCO ESMO - Eur. Oncology global curriculum recommendations for Cancer Care in Older Adults #gerionc Every oncologist should have key competencies in geriatric care! We hope this gets integrated in programs globally @HansWildiers SIOG ascopubs.org/doi/full/10.12…

This trial serves as an important reminder for the fact that ixazomib should have NO role in post-transplant maintenance in the current era! Adds GI toxicities without even a PFS benefit! #mmsm

Halv the older patients with gi cancers experience dizziness and walking impairments after chemotherapy, but it is underreported, as we never ask them! Katrine Storm Piper #SIOG2023 #gerionc

awechalekar ASH2023 Here's a link to the abstract referenced ash.confex.com/ash/2023/webpr… Looking forward to seeing the presentation.

Pleased to share our latest article on why and how drug dose-finding can be tailored to each patient’s risk-benefit trade-offs 👉 journals.sagepub.com/doi/10.1177/17…

A short 1984 chapter by Richard Peto on "The need for ignorance in cancer research" republished today doi.org/10.1007/s10654…… foreshadows much of the progress & stagnation in cancer research over the past 40 yrs; a virtuoso piece, with a commentary here link.springer.com/article/10.100…

Personal reflection: "Clinical prediction models & the multiverse of madness" Thanks to BMC Medicine for 'getting this' Many reviewers/Eds pushed for writing style & tone changes This thread delves into this & why we stuck to our original vision 1/n bmcmedicine.biomedcentral.com/articles/10.11…

👇Thoroughly enjoyed this outstanding paper Ian Marschner. Perhaps a useful interpretation of Conf(BENEFIT)=0.94 is that the region of θ values corresponding to BENEFIT has 4 or less bits of information against it as per Sander Greenland & Sir Panda (Zad Rafi) 👉 bmcmedresmethodol.biomedcentral.com/articles/10.11…

Further discussion on this topic in the #DataMethods forum here: discourse.datamethods.org/t/random-vs-fi… Frank Harrell Sander Greenland

Effect of home-based resistance training on chemotherapy relative dose intensity and tolerability in colon #cancer: The FORCE randomized control trial. acsjournals.onlinelibrary.wiley.com/doi/10.1002/cn… ACS Research ACS Journal Cancer Dana-Farber #ExerciseOncology #CancerResearch #SuppOnc

Dr Amol Akhade ASCO OncoAlert Toni Choueiri, MD Tom Powles Sumanta K. Pal, MD, FASCO Yakup Ergün Yüksel Ürün To help find the answer the question will need to be properly reframed: why did pembrolizumab show a signal of efficacy whereas nivolumab was inconclusive? See section 10 “Comparative and Group-specific inferences” here for the tools needed 👇

💯 Real world evidence is marketing terminology for the old “observational evidence” and implies that somehow RCTs don’t happen in the “real world”. Complete BS

T cell exhaustion markers in multiple myeloma patients before and after physical activity intervention - Joseph et al. #ASCO23 Abstract 8060 meetings.asco.org/abstracts-pres… #mmsm #ImmunoOnc HT @rahulbanerjeeMD

Racial differences in body composition and survival among older adults with gastrointestinal malignancies geriatriconcology.net/article/S1879-… Mackenzie Fowler, PhD Smit Giri MD MHS Grant R. Williams, MD, MSPH, FASCO William Dale, MD, PhD, FASCO @rochgerionc Cancer and Aging Research Group (CARG) #GeriOnc #GeriOnc #OlderAdults #OncoAlert #SIOG #YoungSIOG #RacialDisparities

Geriatric assessment-identified impairments and frailty in adults with cancer younger than 65: An opportunity to optimize oncology care geriatriconcology.net/article/S1879-… Mackenzi Pergolotti PhD OTR/L Smit Giri MD MHS Grant R. Williams, MD, MSPH, FASCO William Dale, MD, PhD, FASCO @rochgerionc Cancer and Aging Research Group (CARG) #GeriOnc #GeriOnc #OlderAdults #OncoAlert

Underutilization of guideline‐rec supportive care among older adults w/ myeloma in US [Aug 5, 2019] Smit Giri MD MHS et al ACS Journal Cancer ow.ly/s3Kb30pl8yw #mmsm #SuppOnc #IDonc #geriheme #cancerdisparities lower odds of influenza vaccination in 1st yr of Dx if Black & Medicaid