🧬 The SMaHT marker paper is now live in nature This landmark study characterizes somatic variation across 19 tissue types from 150 nondiseased donors, laying the groundwork for future discoveries in health, aging, and disease. Read the full paper: nature.com/articles/s4158…

“Until we understand what is happening in healthy people, we can’t understand what is happening in disease.” – Flora Vaccarino SMaHT is cataloging somatic mutations across the human body to better understand health, aging & disease. Learn more... news.yale.edu/2025/07/02/cha…

🎬 Volume 2 of the SMaHT Network Q&A is here! In this edition, SMaHT members weigh in on major challenges in somatic mosaicism research, how the network is addressing them, and why this work matters for understanding human health. youtube.com/@SMaHTnetwork

Catch us over on #Bluesky 👋🏽 bsky.app/profile/smahtn…

The 2025 SMaHT Annual Meeting brought together researchers from across the network and the globe. 🌎 A wonderful few days of collaboration, conversation, and connection. To hear directly from SMaHT members: youtube.com/@smahtnetwork

The Coorens group at EMBL-EBI is hiring a postdoc! 📍 Hinxton, UK 🗓️ Apply by July 25 embl.wd103.myworkdayjobs.com/EMBL/job/Hinxt…

SMaHT is building the first large-scale catalog of somatic variation... DNA changes that occur as we grow and age. These changes create mosaic patterns across tissues and may hold clues to understanding human health and disease. Explore the project: smaht.org/overview/

Research is revealing that the human germline is derived evenly from the first two cells after fertilization, unlike somatic tissues, which exhibit unbalanced lineage allocation. Uncover the science behind it: pmc.ncbi.nlm.nih.gov/articles/PMC11…

“It’s changing how we think about aging and development…” Shadi Z., PhD, shares how somatic mosaicism reveals patterns of tissue function and aging. Watch more from the SMaHT Network Q&A: youtube.com/@smahtnetwork

Nearly 1 in 4 adults with nonsyndromic thoracic aortic aneurysm (TAA) carried likely contributory genetic variants, pointing to a bigger genetic role in TAA than expected. Genetic testing could be the missing link to improving patient care. pmc.ncbi.nlm.nih.gov/articles/PMC11…

To advance research and deepen our understanding of human health, SMAHT is building the first large-scale catalog of somatic mosaicism... DNA changes that happen as we grow and age. learn more: smaht.org

As we age, tiny DNA changes called mosaic structural variants (mSVs) build up in our blood stem cells.... A new study shows how they can disrupt cell function & may influence aging and disease risk. Uncover the research behind it: pmc.ncbi.nlm.nih.gov/articles/PMC11…

"This somatic mutation exploration project offers us one more lens into what disease mechanisms might be driven by molecular factors.” - Richard Gibbs, PhD Hear more perspectives from the SMaHT Network in our Q&A series! youtube.com/@SMaHTnetwork

A recent sequencing method detects single-strand DNA events before they become permanent mutations, further advancing our understanding of cancer, aging & genetic disease. Uncover the science behind it biorxiv.org/content/10.110…

🧬 The SMaHT Network is working to transform our understanding of how somatic mosaicism shapes human biology, development, and disease. Learn more about the mission driving this research in our new video: youtube.com/watch?v=8KX3lk…

An innovative and fascinating sequencing tech detects DNA changes before they lock in as mutations... offering fresh insight into cancer, aging, & genetic disease. Explore the science behind it: biorxiv.org/content/10.110…

"The ultimate goal is to create more personalized medicine and a healthier society.” In our Q&A series, SMaHT members dive into how studying somatic mosaicism can transform our understanding of human health and disease. More on the SMaHT YouTube channel: youtube.com/@smahtnetwork

snapTotal-seq captures both spliced & unspliced RNA in single cells, advancing RNA velocity, revealing key regulators of the cell cycle & senescence, and highlighting post-transcriptional control. Uncover the science behind it: pmc.ncbi.nlm.nih.gov/articles/PMC11…

SMaHT is headed to #ASHG25! Join us in Boston, October 14 - 18, where members of the network will present throughout the meeting, sharing insights on somatic mosaicism and the future of human genetics. See you there!

Emerging perspective in Cell: single-cell reference mapping could transform data integration across diseases, modalities, and species, replacing traditional clustering workflows. Uncover the science behind it: cell.com/cell/fulltext/…