To identify fundamental neuroscientific principles that generalize across species, systems and circuits, neuroscientists must embrace an evolutionary perspective, argue Karl Farrow and Katja Reinhard. thetransmitter.org/systems-neuros…

Together we go farther. Thanks to a partnership with Aligning Science Across Parkinson’s and michaeljfox.org, the Allen Institute's ABC Atlas now includes #ParkinsonsDisease data from 3 million brain cells from 9 regions. This is the first time Parkinson’s data has been included in the Atlas. It

#eNeuro | CalTrig: A GUI-Based Machine Learning Approach for Decoding Neuronal Calcium Transients in Freely Moving Rodents vist.ly/3yhqy

Inflammation can spike depression This is a 𝘳𝘢𝘯𝘥𝘰𝘮𝘪𝘻𝘦𝘥 𝘵𝘳𝘪𝘢𝘭 of placebo vs. endotoxin (which is what makes certain bacteria inflammatory – it's in the membrane) in older adults Endotoxin spiked depressive symptoms – but only in those with insomnia

In this review article, the authors highlight the distinct neuroanatomical and temporal dynamics of the non-motor aspects of PD and explore the possibility of developing adaptive DBS for non-motor symptoms. A "must-read" article for DBS-enthusiasts! loom.ly/FCX82rw

Could a virus be behind the cause of Parkinson’s disease? Spoiler alert: New exciting data on the 'pegivirus' has arrived. In a discovery that echoes the once-radical link between Helicobacter pylori and peptic ulcer disease, researchers have found human pegivirus (HPgV) in the

A role for the thalamus in danger evoked awakening during sleep nature.com/articles/s4146…

Revisiting brain gene expression changes and protein modifications tracking homeostatic sleep pressure | npj Biological Timing and Sleep nature.com/articles/s4432…

Hallmarks and mechanisms of cellular senescence in aging and disease nature.com/articles/s4142…

Potentiation of mitochondrial function by mitoDREADD-Gs reverses pharmacological and neurodegenerative cognitive impairment in mice | Nature Neuroscience nature.com/articles/s4159…

Optimized DBS for ACC inhibition produces antidepressant-like effects in mice cell.com/neuron/fulltex…

What is the 2025 update on glymphatic dysfunction and Parkinson’s disease? The brain’s waste-clearance system called the ‘glymphatics’ may be failing in Parkinson’s, leaving behind toxic proteins like α-synuclein. A new systematic review and meta-analysis sheds light on this

Collaboration, not competition, will map the future of human biology. The Billion Cell Project brings together 10 institutions, over 100 experts, 10 research centers + a shared vision: unlocking biological insight at #SingleCell resolution. bit.ly/3U31D1e

A large-scale study in Health Data Science (PMID: 40464054) found that poor sleep patterns were linked to 172 diseases, including dementia, Parkinson’s disease, diabetes, and kidney failure. Importantly, 92 of those diseases had more than 20% of their risk attributable to poor

Happy to announce our new paper just out: rdcu.be/eBpGY We show how CRH in the thalamic reticular nucleus modulates NREM sleep helping to understand how stress impacts sleep Congrats to Loredana Cumpana and team in work led by Simone Astori EPFL Brain Mind Institute EPFL

Cave adaptation favors aging resilience in the Mexican tetra nature.com/articles/s4432…

Exposing mice to 11% oxygen (vs 21% normal) not only prevented Parkinson's symptoms but reversed motor dysfunction 6 weeks after onset.

Link to paper by Dr. Adiv Johnson link.springer.com/article/10.100…

💤In this week's Science Friday: A study led by Dr. Francesco Bavato demonstrates that gamma-hydroxybutyrate (GHB) prolongs slow-wave sleep and has more favourable effects on next-day vigilance compared to trazodone and a placebo. Read more here: esrs.eu/news/sleep-sci…

Are thalamocortical networks implicated ASD? Sung-Soo Jang's work in our lab with Cntnap2-/- mice demonstrates thalamic (RT) involvement and that thalamically targeted therapies improve ASD symptoms. tinyurl.com/4tyxtpus