Aging predictions can be based on functional biomarkers mechanistically linked to aging, such as polyamines and protein carbamylation. Why do people still use phenomenological biomarkers with unclear functional and mechanistic links, such as DNA methylation?

Interesting questions: Why long-lived proteins exist in metabolically active cellular environments ? How are these proteins maintained over time ?

Similarities:

I am looking forward to ICSB next week. I will present: 1⃣ New technology from Parallel Squared Technology Institute (PTI): parallelsq.org/blog/proteomic… 2⃣ New biology from Slavov Laboratory: biorxiv.org/content/10.110…

A compelling illustration of the difference between mRNA abundance, ribosome density and protein abundance.