Joao Luiz (@silvafilhojl) 's Twitter Profile
Joao Luiz

@silvafilhojl

Immunologist, researching infectious diseases for precision medicine. Love to code, gaming, and playing with spatial and systems biology approaches.

ID: 132255931

calendar_today12-04-2010 18:43:20

1,1K Tweet

274 Followers

327 Following

Fabian Theis (@fabian_theis) 's Twitter Profile Photo

Single-cell multiplexing (hashing/genetics) is key for upscaling scRNA-seq. We introduce hadge, a Nextflow pipeline combining existing comp analysis methods with new metrics & rescue mode for efficient deconvolution. Led by F Curion, X Wu & Lukas Heumos. biorxiv.org/content/10.110…

Single-cell multiplexing (hashing/genetics) is key for upscaling scRNA-seq. We introduce hadge, a Nextflow pipeline combining existing comp analysis methods with new metrics &amp; rescue mode for efficient deconvolution. Led by F Curion, X Wu &amp; <a href="/LukasHeumos/">Lukas Heumos</a>. biorxiv.org/content/10.110…
medRxiv (@medrxivpreprint) 's Twitter Profile Photo

Disease trajectories in hospitalized COVID-19 patients are predicted by clinical and peripheral blood signatures representing distinct lung pathologies. medrxiv.org/cgi/content/sh… #medRxiv

Joao Luiz (@silvafilhojl) 's Twitter Profile Photo

Interesting comparison of Xenium vs CosMx spatial molecular imagers data indicating which one performs better in the same set of samples. I always said “cell segmentation” is the most critical factor…#spatial #transcriptomics #ST

Joao Luiz (@silvafilhojl) 's Twitter Profile Photo

Happy to have contributed to the development another spatially-resolved single-cell atlas of the post-mortem lung also from another “underrepresented” population in studies of this kind. #spatial #biology #singlecellspatial #humancellatlas

Joao Luiz (@silvafilhojl) 's Twitter Profile Photo

Playing with new tools for alignment and spatially-aware integration of adjacent sections and from different samples for multi-modal spatial omics. Benchmarks shows massive improvement over “traditional” spatially-unaware tools such as harmony #spatial #spatialomics #bioinfo

Playing with new tools for alignment and spatially-aware integration of adjacent sections and from different samples for multi-modal spatial omics. Benchmarks shows massive improvement over “traditional” spatially-unaware tools such as harmony #spatial #spatialomics #bioinfo
Cell (@cellcellpress) 's Twitter Profile Photo

Now online! Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging dlvr.it/T6Vv5L

Joao Luiz (@silvafilhojl) 's Twitter Profile Photo

Few lines on code and expression of 5K genes are imputed/predicted in a 1K-panel spatial transcriptomics dataset, with uncertainties leveraged in downstream analysis #spatial #biology #spatialtranscriptomics #bioinformatics

Few lines on code and expression of 5K genes are imputed/predicted in a 1K-panel spatial transcriptomics dataset, with uncertainties leveraged in downstream analysis #spatial #biology #spatialtranscriptomics #bioinformatics
Joao Luiz (@silvafilhojl) 's Twitter Profile Photo

After cell segmentation, I find suitable normalisation methods for spatial transcriptomics data another step requiring further development in the spatial biology field. #spatial #transcriptomics #data biorxiv.org/content/10.110…

Joao Luiz (@silvafilhojl) 's Twitter Profile Photo

As a newbie analysing ST data in different tumour datasets, I find this study quite interesting when I’ve observed strong and diverse B-cell signatures in such tumours. #spatial #transcriptomics #tumour #biology #bcells

Joao Luiz (@silvafilhojl) 's Twitter Profile Photo

Great discussions last night presenting our spatial single-cell omics work in vivax malaria at the Brazilian Malaria Meeting. Now, time to fly to New Orleans for AsTMH #rnm#reuniao#nacional#malaria#astmh

Great discussions last night presenting our spatial single-cell omics work in vivax malaria at the Brazilian Malaria Meeting. Now, time to fly to New Orleans for AsTMH #rnm#reuniao#nacional#malaria#astmh
Joao Luiz (@silvafilhojl) 's Twitter Profile Photo

So happy to have directly contributed to this effort and achievement! Find our spatial lung cell atlas in respiratory disease in an African population here: doi.org/10.1038/s41591… nature.com/articles/d4158…