🚨 Science Magazine paper alert 👉 A novel chemical labeling method allows transient events in cells to be recorded for later analysis. Congrats to Magnus Huppertz and Jonas Wilhelm and their collaboration partners MPI for Biological Intelligence, DKFZ and HHMI | Janelia! mr.mpg.de/14594969/recor…

Wow, huge scale electrophysiological screen in iPSC neurons. 30,000 compounds screened to rescue a TSC2 loss of function phenotype (all optical!) They found the phenotype w CRISPR & patient cell lines, in ephys, morphology, and mRNA. (I’m on Quiver SAB) biorxiv.org/content/10.110…

HOPPLA! it is finally published in PLOS Genetics 🌾! Thanks @roulinlab and everyone involved in this great project 🙏

30-COLOR DNA-PAINT at 3D sub-15 nm RESOLUTION. We are overly excited to announce the publication of our latest work “Spatial proteomics in neurons at single-protein resolution” in Cell. Huge collaborative effort led by Eduard Unterauer. 1/9 cell.com/cell/fulltext/…

Our lab is growing, rapidly! Join us in Zurich, working on this beautiful topic of #embryology

Please repost 🙏 We have an open position for a solid state NMR spectroscopist at the interface of energy materials and quantum technologies. Within the project the candidate will develop novel NV-based NMR methods to probe thin film battery materials and catalysts.

🙋🏻🔬 #EMBOinsitu is open for registrations! From cryo-EM to multi-scale modelling - what types of biological questions can be addressed using in situ structural biology? 📜 Submit abstract by 12 Nov 📅 4 – 7 Feb 2025 📍 EMBL Heidelberg and Virtual ➡️ s.embl.org/iss25-01

Switch on ... Excited to share thoughts on switching proteins in Photo/Optoacoustics together with Vasilis Ntziachristos in Nature Methods . Support for ongoing work from @erc_research #Switch2See , MunichImaging , Helmholtz Munich | @HelmholtzMunich , Universität Regensburg

Controlling the absorption of certain molecules imparts new opportunities for high-resolution #optoacoustic biological imaging, much deeper than what is possible by optical microscopy. We argue that such absorption-switchable labels may play for optoacoustic imaging the same role

So happy to announce the next Helmholtz Pioneer Campus (HPC) Principal Investigator (f/m/x) recruitment round to promote wonderful young talent in Bioengineering and Biomedicine. nature.com/naturecareers/…

APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2

New paper out at ACS Nano. Awesome work by PhD student Seokmu Kwon (Seokmu Kwon) and postdoc Mike Andreas! pubs.acs.org/doi/abs/10.102…

New paper out Nature Communications. Tremendous work by postdoc Mike Andreas, congrats! nature.com/articles/s4146…

Check out our approach on "non-destructive transcriptomics via vesicular export" (NTVE)! We have benchmarked NTVE exclusively in stably integrated cell lines, where transcript alterations by perturbations were truthfully reflected in the supernatant. ,biorxiv.org/content/10.110…

Excited to share 'non-destructive transcriptomics via vesicular export' (NTVE). We use HIV-1 virus-like particles, to export 'snapshots' of a cell’s transcriptome, which allows to follow gene expression changes over time by sampling from the supernatant. biorxiv.org/content/10.110…

In our new paper we extended modules for building protein polyhedral cages from coiled-coil (CC) dimers to tetrameric CCs. This introduced many new topological possibilities and allowed assembly of dimeric cages. onlinelibrary.wiley.com/doi/10.1002/an… 🧵

Schroeder Lab website is now live! 🔥 Check it out 🤩 to learn about who we are, what we do to study how the brain gives rise to internal states that drive adaptive behavior 🧠, and how you can join the team 👇 Spread the word! annaschroederlab.com

Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" biorxiv.org/content/10.110… We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during vesicle fusion ❄️🔬⏱️

doi.org/10.1016/j.cell… ENVLPE, our system for VLP-based delivery of gene editors, is now published in Cell. We showed efficient delivery of base- and prime-editors in primary T cells & in vivo retinal models. Congrats co-first-authors Julian Geilenkeuser & Niklas Armbrust!

Engineering Smart Delivery for Gene Editors 🧬 👉t1p.de/vmdc9 A research team from #HelmholtzMunich and TU München has developed an advanced delivery system that transports gene editing tools based on the CRISPR/Cas9 gene-editing system into living cells with