In science, who gets grants and pubs depends on peer review. Does reviewer diversity matter? Yes! In new paper led by James M. Zumel Dumlao we establish a subtle structural bias we call geographical representation bias that benefits authors from wealthier countries (1/3)

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. biorxiv.org/content/10.110… (1/n)

and consider joining us and working on AI models that address significant challenges in biology, such as the development of RNA therapeutics or the understanding of cancer genomes. Be free to DM me. #AI #Biology #ResearchOpportunity 2/2

The results are in: top codes in Stanford #RNA 3D Folding Kaggle are competitive with CASP16-leading humans Vfold, beat AlphaFold 3. Top team’s trick was template-based modeling, not #DeepLearning. Congrats: john, odat, Eigen, + all 1706 participants! kaggle.com/competitions/s…

In GIS, we aim to use the power of genomics to make the world a better place. We are happy to be able to celebrate 25 years years of excellence with outstanding scientists in Singapore and across the world.

Very interesting results. This opens a few questions. 1) is RNA structure prediction well posed problem due to RNA flexibility 2) how can we use non DL approaches to move the field forward 3) how far can we go with structural probing data

A model developed with data from 19,403 patients with #colorectal #cancer for prediction of one-year mortality is used as a decision support tool in a prospective cohort, showing promising results in reducing post-operative complications. #CancerPrediction #DecisionSupport

Excited to share our new protocol article! We present step-by-step workflows for STARmap PLUS, RIBOmap and TEMPOmap.

How can spatial transcriptomics achieve whole-genome coverage while maintaining single-molecule resolution without requiring sequencing?Cell Yale School of Medicine "Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution" • RAEFISH addresses the

What if your mitochondria could leave your cell… and rescue someone else’s? (Spoiler: they can. But it’s not always a rescue.) : This blew me away. A Nature paper just showed that brown fat cells, the ones you activate with cold exposure , can export mitochondria directly into

Finding somatic mutations in healthy tissue that can lead to cancer, at scale. Yet another path to primary prevention nature.com/articles/s4158… nature.com/articles/d4158…

We’re opening several postdoctoral and scientist positions focused on RNA structure prediction and mRNA drug optimisation at the A*STAR Genome Institute of Singapore (A*STAR GIS). If you’re passionate about AI for therapeutics — especially in areas like generative models, diffusion models, flow matching, or joint

Years ago we tried to model cancer-associated fibroblast (CAF) subtypes in vitro, but gave up because only the proliferative subtype survived culture (duh!). This study could change all that: Perturb-seq with CRISPRa of 1,836 TFs induces diverse fibroblast states in vitro(!). 👏

We are super proud of our Yale School of Medicine and Clinical-oMx Lab UQ News team for our new publication in Nature Genetics titled “Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer”. Let’s get into it…nature.com/articles/s4158…

Omics showed the power of profiling many genes side by side. Same logic applies here: characterizing multiple disease models in parallel gives more precise insights. Single cell comparative organoidomics of neurodevelopmental disorders is a very promising strategy!

Exciting work! Accurate risk prediction for common age-related diseases like CVD, stroke etc could eventually transform healthcare by enabling prevention and early detection.

🌟GLOW-ing together for better gut health A*STAR Genome Institute of Singapore (A*STAR Genome Institute of Singapore (A*STAR GIS)) is partnering clinicians and scientists from Institute of Mental Health, NHG Polyclinics, Tan Tock Seng Hospital, Duke-NUS Medical School, National University of Singapore, Lee Kong Chian School of

A newly unearthed partial fossil skeleton suggests that an extinct hominid species could have made stone tools around 1.5 million years ago. sciencenews.org/article/fossil…

Emirati Genome Program: - whole genome data from 504,000 individuals - electronic health record data from 426,000 - genetically reconstructed pedigrees applied here to understanding retinal diseases medrxiv.org/content/10.110…

I keep saying these guys are trouble.