I am very happy to share our pre-print on the prototyping of a complex enzyme cascade (the CETCH cycle) using in vitro transcription-based (ROSALIND) biosensors. Thanks to everybody involved. We are looking forward to your feedback! SYBORG doi.org/10.1101/2024.0…

Very excited to share the preprint of a big chapter of my PhD, where I am corresponding & shared first author (together with Tanguy Chotel) about advancing #chloroplast #synbio through high-throughput plastome engineering of #Chlamydomonas: Below in a 🧵: biorxiv.org/content/10.110…

Very happy to share our new work -- A cell-free gene expression-based unified biocatalysis (UniBioCat) system for biosynthesis, engineering, and discovery of RiPPs natural products. Michael C. Jewett ShanghaiTech University link.springer.com/10.1038/s41467…

How can we access new chemical matter to identify new antibiotics? Check out our new work in Nature Communications on using #cellfree #synbio to accelerate discovery and engineering of ribosomally synthesized lanthipeptides with Jian Li nature.com/articles/s4146…

Unveiling the unfamiliar within the familiar: Our latest preprint, in collaboration with UC San Diego Systems Biology, presents a comprehensive study of Extracellular Electron Transfer in E. coli.

I am happy to join the Groningen Biomolecular Sciences and Biotechnology Institute as Assistant Professor in early 2025. My group will engineer microbes to grow on sustainable feedstocks: CO2, Methanol, Formate... Stay tuned for job openings! #youngPI #SustainableBiotech

Super excited to share my main research SYBORG, new in Science Magazine, where I engineered a cell-free system that self-regenerates using building blocks autonomously synthesized from CO2! 🧪🫧 Let me tell you more below 👇 science.org/doi/10.1126/sc…

I am happy to share that our efforts in SYBORG to integrate metabolism with TXTL to build self sustaining life like systems got one step closer. Now out in Science Magazine 🥳 science.org/doi/10.1126/sc…

Excited to share my first corresponding & co-first author paper with Clemens Böhm! We developed cell-free extracts from chloroplasts of various plant species for rapid prototyping, accelerating #plantSynBio in chloroplasts. 🌿 Check it out! pubs.acs.org/doi/10.1021/ac…

Honoured to receive the prize of the Zukunftsforum for my master thesis on the novel reaction of a B12-dependent mutase. I will present the work at the DECHEMA Forum on 12th of September! Many thanks to my thesis supervisors Ari Satanowski SYBORG & collaborator Philipp Wichmann!

Harnessing the high product titers from fermentations for aerobic productions? Metabolic rewiring makes that possible! Read below to get to know my NNmini strain allowing the selective use of respiratory modules to re-balance unbalanced fermentations! nature.com/articles/s4146…

Novel enzyme starts with promiscuity. Excited to share our study that shows how #evolution recruits a single enzyme for multiple purposes, showcasing the plasticity and flexibility of #metabolism. Huge thanks to my colleagues at SYBORG & Max Planck Institute for Terrestrial Microbiology! rdcu.be/dXaqU

New in @EMBOjournal, we studied the evolution of essentiality in Form I Rubisco. While Georg Hochberg nicely summarizes the evolutionary implications of our work, let me summarize some of the cool biochemistry surrounding it. doi.org/10.1038/s44318… 🧵

Lets talk about #acetyl-CoA! As central molecule in C1 metabolism, the efficiency of its assimilation determines yields. Read below about our Lcm as novel activity in the shortest O2 tolerant route to make pyruvate from acetyl-CoA while fixing #CO2! nature.com/articles/s4146…

We are looking for a postdoc - in a project on a UbiD like (de)carboxylase!

📢We invite candidates strongly interested in 𝗶𝗻𝘁𝗲𝗿𝗱𝗶𝘀𝗰𝗶𝗽𝗹𝗶𝗻𝗮𝗿𝘆 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗶𝗻 𝗺𝗼𝗱𝗲𝗿𝗻 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝗹𝗼𝗴𝘆 to apply for 𝗳𝘂𝗹𝗹𝘆-𝗳𝘂𝗻𝗱𝗲𝗱 𝗣𝗵𝗗 𝗽𝗼𝘀𝗶𝘁𝗶𝗼𝗻𝘀. Curious to learn more? See this 🧵 or visit imprs-marburg.mpg.de

Glad to see my main PhD project finally out Nature Microbiology nature.com/articles/s4156… We show for the first time that a synthetic and engineered pathway can indeed exceed nature at one-carbon fixation.

Really happy to share that our work on constructing six glyoxylate / glycolate sensors covering a three order of magnitude concentration range is out now in Nature Communications ! 🔥 Read below to see how we developed the sensors and what they are good for 🥳. nature.com/articles/s4146…

🌿🔬How can we fix #CO2 more efficiently in biological systems? Our new study introduces the CORE cycle, a synthetic pathway that converts CO2 to formate at aerobic conditions and ambient CO2 levels! 🚀🦠 SYBORG Max Planck Institute for Terrestrial Microbiology nature.com/articles/s4146…

Excited to share a main project from my PhD, out now in Nature Communications! 📝 We've designed and brought to life the “CORE cycle” – a new-to-nature pathway that provides a novel route for biological CO2 capture 🦠🌱 nature.com/articles/s4146… Take a look! Thread below... 🧵